System and method for controlling learning period for adaptive noise cancellation

Patent metadata

Field	Value
Publication number	US-9869667-B2
Application number	US-201414540299-A
Country	US
Kind code	B2
Filing date	Nov 13, 2014
Priority date	Nov 13, 2014
Publication date	Jan 16, 2018
Grant date	Jan 16, 2018

Abstract

A data acquisition system coupled to a mains power source and a method of operating the data acquisition system are disclosed. A test probe is configured to be coupled to a subject, and an analog to digital converter converts a signal from the test probe to samples. A noise replica generator generates estimates of noise in the samples, and a noise removal block removes from each sample an estimate of noise therein. When the subject is undergoing stimulation, the samples are provided to only the noise removal block. When the subject is not undergoing stimulation, the samples are provided to both the noise replica generator and the noise removal block.

First claim

We claim:

1. A data acquisition system coupled to a mains power source that provides cyclical periods of power, comprising:
a test probe configured to be coupled to a subject;
an analog to digital converter that converts a signal from the test probe to samples;
a noise replica generator that generates estimates of noise in the samples;
a noise removal block that removes from each sample an estimate of noise therein;
a period detector that detects starts of first and second cyclical periods of the power provided by the mains power source and generates a signal indicating each such start, wherein the second cyclical period precedes the first cyclical period;
a stimulus generator that monitors the signal generated by the period detector and applies stimulation to the subject during the first cyclical period of the power, does not apply stimulation to the sample during the second cyclical period of power, and generates a gating signal during the second cyclical period of the power; and
a gating module that monitors the gating signal and determines when the subject is undergoing stimulation, wherein the gating module provides the samples to the noise removal block and not to the noise replica generator when the subject is undergoing stimulation, and provides samples to both the noise replica generator and the noise removal block when the subject is not undergoing stimulation.

2. The data acquisition system of claim 1 , wherein the gating module does not provide any samples to the noise replica generator during the cyclical period during which stimulation is to be applied.

3. The data acquisition system of claim 1 , wherein the stimulus generator provides an indication to the gating module that the subject will undergo stimulation prior to each of a plurality of cyclical periods during which stimulation is applied to the subject.

4. The data acquisition system of claim 1 , wherein the stimulus generator provides an indication the stimulation is to cease during a third cyclical period.

5. The data acquisition system of claim 1 , wherein the stimulus generator causes the stimulation to be provided to the subject.

6. The data acquisition system of claim 1 , wherein the subject is a biological sample.

7. A method of operating a data acquisition system coupled to a mains power source, wherein the mains power source provides cyclical periods of power, comprising:
receiving an analog signal from a test probe coupled to a subject;
converting the analog signal into samples;
operating a noise replica generator that generates estimates of noise in the samples;
operating a noise removal block that removes from each sample an estimate of noise therein;
detecting starts of first and second cyclical periods of power provided by the mains power source, wherein the second cyclical pried precedes the first cyclical period;
applying stimulation to the subject during the first cyclical period and not applying stimulation to the subject during the second cyclical period;
generating a gating signal during the second cyclical period; and
monitoring the gating signal to determine when the subject is undergoing stimulation and providing the samples to the noise removal block and not the noise replica generator when the subject is undergoing stimulation, and providing the samples to both the noise replica generator and the noise removal block when the subject is not undergoing stimulation.

8. The method of claim 7 , further including generating a signal that the subject will undergo stimulation prior to each of a plurality of cyclical periods during which stimulation is applied to the subject.

9. The method of claim 8 , wherein no samples are provided to the noise replica generator during the cyclical period during which stimulation is to be applied.

10. The method of claim 9 , further including generating a signal that stimulation will be applied to the subject during a third cyclical period and another signal that the stimulation is to cease during a fourth cyclical period.

11. The method of claim 9 , further including causing stimulation to be provided to the subject.

12. The method of claim 7 , further including coupling the test probe to a subject that is a biological sample.

Assignees

• Molecular Devices Llc

Inventors

• Blizard Benjamin
• Youngquist Michael
• Tang Kachoi
• Sridhar Krithika

Classifications

• G01R29/26

  Measuring noise figure; Measuring signal-to-noise ratio · CPC title

• A61B5/7278

  Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals · CPC title

• G01N33/48728 Primary

  Investigating individual cells, e.g. by patch clamp, voltage clamp (investigating individual particles in general G01N15/10) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• H04B1/1018

  noise filters connected between the power supply and the receiver · CPC title