Asgpr-binding compounds for the degradation of extracellular proteins
US-2024424108-A1 · Dec 26, 2024 · US
US9868754B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9868754-B2 |
| Application number | US-201214237795-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 8, 2012 |
| Priority date | Aug 8, 2011 |
| Publication date | Jan 16, 2018 |
| Grant date | Jan 16, 2018 |
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The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Opening claim text (preview).
The invention claimed is: 1. A method of alleviating or treating an inflammatory disorder in a human subject, comprising: administering to the subject a composition comprising isolated ascr#7 or a salt thereof; and wherein the inflammatory disorder is asthma, inflammatory bowel disease, or type one diabetes. 2. The method of claim 1 , wherein the method reduces mucus production in the subject. 3. The method of claim 1 , wherein the naturally occurring ascaroside is produced from a Nippostrongylus brasiliensis. 4. The method of claim 1 , wherein the inflammatory disorder is asthma. 5. The method of claim 1 , wherein the inflammatory disorder is inflammatory bowel disease. 6. The method of claim 1 , wherein the inflammatory disorder is type one diabetes.
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