Carrier for blood component adsorption and blood component adsorption column

Patent metadata

Field	Value
Publication number	US-9867927-B2
Application number	US-201214001065-A
Country	US
Kind code	B2
Filing date	Feb 24, 2012
Priority date	Feb 25, 2011
Publication date	Jan 16, 2018
Grant date	Jan 16, 2018

Abstract

A carrier for blood component adsorption enables selective and efficient adsorption removal of granulocytes and monocytes and, at the same time, enables adsorption removal of inflammatory cytokines. The carrier for blood component adsorption includes a water-insoluble carrier having a surface to which a functional group(s) containing a silyl group and an amino group is/are introduced.

First claim

The invention claimed is:

1. A carrier for blood component adsorption comprising a water-insoluble carrier having a surface to which a functional group(s) containing a silyl group and an amino group is/are introduced, wherein said silyl group is terminally positioned in both the functional group and the water-insoluble carrier, wherein said water-insoluble carrier is polyolefin, fluorinated polymer, polysulfone-based polymer, polyetherimide, polyimide, polyamide, polyether, polyphenylene sulfide, polystyrene, acrylic polymer or a blend or alloy thereof, and wherein the water-insoluble carrier is functionalized with a reactive functional group(s) reactive with said amino group before introducing the functional group(s) containing the silyl group and the amino group to the carrier, wherein the reactive functional group(s) is selected from the group consisting of halomethyl group, haloacetyl group, haloacetamidomethyl group and halogenated alkyl group, epoxide group, isocyanate group, thioisocyanate group and acid anhydride group.

2. The carrier according to claim 1 , wherein said water-insoluble carrier has a proton adsorption capacity of 1.5×10 −5 to 3.0×10 −3 eq/g.

3. The carrier according to claim 1 , wherein the silicon atom of said silyl group and the nitrogen atom of said amino group are linked together by an alkyl chain.

4. The carrier according to claim 3 , wherein said alkyl chain is an alkyl chain having not more than 6 carbon atoms.

5. The carrier according to claim 1 , wherein said silyl group has an alkyl group and/or alkoxy group.

6. The carrier according to claim 5 , wherein said alkyl group is a methyl group or ethyl group.

7. The carrier according to claim 5 , wherein said alkoxy group is a methoxy group or ethoxy group.

8. The carrier according to claim 1 , wherein said water-insoluble carrier is composed of a fiber or particle.

9. The carrier according to claim 8 , wherein said fiber has a fiber diameter of, or said particle has a particle diameter of, 0.5 to 20 μm.

10. A column for blood component adsorption filled with the carrier for blood component adsorption according to claim 1 .

11. The carrier according to claim 2 , wherein the silicon atom of said silyl group and the nitrogen atom of said amino group are linked together by an alkyl chain.

12. The carrier according to claim 2 , wherein said silyl group has an alkyl group and/or alkoxy group.

13. The carrier according to claim 3 , wherein said silyl group has an alkyl group and/or alkoxy group.

14. The carrier according to claim 4 , wherein said silyl group has an alkyl group and/or alkoxy group.

15. The carrier according to claim 6 , wherein said alkoxy group is a methoxy group or ethoxy group.

16. The carrier according to claim 2 , wherein said water-insoluble carrier is composed of a fiber or particle.

17. The carrier according to claim 3 , wherein said water-insoluble carrier is composed of a fiber or particle.

18. The carrier according to claim 4 , wherein said water-insoluble carrier is composed of a fiber or particle.

19. The carrier according to claim 5 , wherein said water-insoluble carrier is composed of a fiber or particle.

20. The carrier according to claim 6 , wherein said water-insoluble carrier is composed of a fiber or particle.

21. The carrier according to claim 1 , wherein said water-insoluble carrier is poly(p phenylene ether sulfone) or an alloy of polystyrene and polypropylene.

22. The carrier according to claim 1 , wherein said amino group is a secondary or tertiary amino group, or a quaternary ammonium group.

Assignees

• Tomita Naotoshi
• Ueno Yoshiyuki
• Tanahashi Kazuhiro
• Toray Industries

Inventors

• Tomita Naotoshi
• Ueno Yoshiyuki
• Tanahashi Kazuhiro

Classifications

• B01J2220/58

  Use in a single column · CPC title

• B01J20/3293

  Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers · CPC title

• B01J20/3259

  comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom · CPC title

• B01J20/3257

  the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such · CPC title

• B01J20/3251

  comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur · CPC title