Medical material and hollow fiber membrane module

Patent metadata

Field	Value
Publication number	US-9867917-B2
Application number	US-201113997459-A
Country	US
Kind code	B2
Filing date	Dec 27, 2011
Priority date	Dec 28, 2010
Publication date	Jan 16, 2018
Grant date	Jan 16, 2018

Abstract

The present invention provides a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a medical material which has a hydrophilic copolymerization polymer present on a surface thereof which is to be in contact with blood, wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood at a density of 3 particles/μm 2 or less and the relaxation time of adsorbed water in the hydrophilic copolymerization polymer is 2.5×10 −8 seconds or shorter and 5.0×10 −10 seconds or longer at −40° C.

First claim

The invention claimed is:

1. A hollow fiber membrane module comprising:
a hollow fiber membrane bundle which is composed of hollow fiber membranes, each hollow fiber membrane having, on a surface thereof which is to be in contact with blood, a hydrophilic copolymer having a relaxation time of adsorbed water of 2.5×10 −8 seconds or shorter and 5.0×10 −10 seconds or longer at −40° C.;
a main body case in which the hollow fiber membrane bundle is stored;
partitioning walls which enable the hollow fiber membrane bundle to be held in a liquid-tight state at both ends of the main body case while keeping hollow fiber membranes in an opened state; and
headers which are respectively attached to both ends of the main body case and through which blood can be introduced and led out; and
zones A to H, which are produced by dividing a region lying between a position corresponding to the inner diameter (D 0 ) of each of the headers and a position 1 mm apart from the aforementioned position toward the inner periphery into equal 8 parts equiangular with the center of axis of the main body case as its center in an edge face of each of the partitioning walls on a side facing each of the headers;
wherein each of zones A to H are configured to have a hollow fiber membrane packing density within the range from 13 to 40%, and the overall packing density of the edge face of each of the partitioning walls is within the range of 53 to 64%;
wherein the partitioning wall edge faces contain dispersed hollow fiber membranes,
wherein a flexible layer is present on the surface which is to be in contact with blood in each of the hollow fiber membranes when the hydrophilic copolymer is in a moistened state and the flexible layer has a thickness of 7 nm or more; and
wherein particulate protuberances each having a particle diameter of 50 nm or more are present on the surface which is to be in contact with blood in each of the hollow fiber membranes within a density range of from 0.1 particles/μm 2 to 3 particles/μm 2 .

2. The hollow fiber membrane module according to claim 1 , wherein the amount of the hydrophilic copolymer on the surface which is to be in contact with blood in each of the hollow fiber membranes is 5 to 30% by weight of the hollow fiber membrane.

3. The hollow fiber membrane module according to claim 1 , each hollow fiber membrane having a crimp structure, and the wave height of the crimp structure is within the range from 0.1 mm to 1.5 mm.

4. The hollow fiber membrane module according to claim 1 , each hollow fiber membrane having a crimp structure, and the wave length is within the range from 5 mm to 30 mm.

Assignees

• Ueno Yoshiyuki
• Fujita Masaki
• Sugaya Hiroyuki
• Hashimoto Kazuyuki
• Terasaka Hiroyuki
• Koganemaru Ryo
• Toray Industries

Inventors

• Ueno Yoshiyuki
• Fujita Masaki
• Sugaya Hiroyuki
• Hashimoto Kazuyuki
• Terasaka Hiroyuki
• Koganemaru Ryo

Classifications

• B01D71/68

  Polysulfones; Polyethersulfones · CPC title

• B01D69/084

  Undulated fibres · CPC title

• B01D69/02

  characterised by their properties · CPC title

• A61L33/062 Primary

  Mixtures of macromolecular compounds · CPC title

• B01D67/0088

  Physical treatment with compounds, e.g. swelling, coating or impregnation · CPC title