Technologies for white matter hyperintensity quantification

Patent metadata

Field	Value
Publication number	US-9867566-B2
Application number	US-201514947704-A
Country	US
Kind code	B2
Filing date	Nov 20, 2015
Priority date	Nov 21, 2014
Publication date	Jan 16, 2018
Grant date	Jan 16, 2018

Abstract

A method comprises selecting, via a computer, an intensity threshold value. The method also comprises defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value. The method further comprises extracting, via the computer, a plurality of voxels from the imaging data based on the defining. The method additionally comprises determining, via the computer, a total volume of the voxels based on the extracting. The method also comprises determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.

First claim

The invention claimed is:

1. A method comprising:
selecting, via a computer, an intensity threshold value;
defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
determining, via the computer, a total volume of the voxels based on the extracting; and
determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.

2. The method of claim 1 , wherein the selecting is based on an image analysis based on at least one of image brightness information, image historic information, image degradation information, or imaging machine information.

3. The method of claim 1 , further comprising:
analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity.

4. The method of claim 3 , further comprising:
editing, via the computer, the imaging data based on the analyzing.

5. A system comprising:
a hardware processor;
a memory operably coupled to the hardware processor, wherein the memory storing a set of instructions for execution via the hardware processor, wherein the set of instructions instructs the hardware processor to perform a method comprising:
selecting an intensity threshold value;
defining a plurality of hyperintensities on imaging data based on the intensity threshold value;
extracting a plurality of voxels from the imaging data based on the defining;
determining a total volume of the voxels based on the extracting; and
determining a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.

6. The system of claim 5 , wherein the selecting is based on image analysis based on at least one of image brightness information, image historic information, image degradation information, or imaging machine information.

7. The system of claim 5 , wherein the method further comprising:
analyzing the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity.

8. The system of claim 7 , wherein the method further comprising:
editing the imaging data based on the analyzing.

9. A non-transitory computer-readable storage medium storing a set of instructions for execution via a processing circuit to implement a method comprising:
selecting, via a computer, an intensity threshold value;
defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
determining, via the computer, a total volume of the voxels based on the extracting; and
determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.

10. The non-transitory computer-readable storage medium of claim 9 , wherein the selecting is based on image analysis based on at least one of image brightness information, image historic information, image degradation information, or imaging machine information.

11. The non-transitory computer-readable storage medium of claim 9 , wherein the method further comprising:
analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity.

12. The non-transitory computer-readable storage medium of claim 11 , wherein the method further comprising:
editing, via the computer, the imaging data based on the analyzing.

13. A method comprising:
selecting, via a computer, an intensity threshold value;
defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
determining, via the computer, a total volume of the voxels based on the extracting; and
determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.

14. The method of claim 13 , wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.

15. The method of claim 13 , wherein the selecting is based on an image analysis based on at least one of image brightness information, image historic information, image degradation information, or imaging machine information.

16. The method of claim 13 , further comprising:
editing, via the computer, the imaging data based on the analyzing.

17. A system comprising:
a hardware processor;
a memory operably coupled to the hardware processor, wherein the memory storing a set of instructions for execution via the hardware processor, wherein the set of instructions instructs the hardware processor to perform a method comprising:
selecting an intensity threshold value;
defining a plurality of hyperintensities on imaging data based on the intensity threshold value;
analyzing the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
extracting a plurality of voxels from the imaging data based on the defining;
determining a total volume of the voxels based on the extracting; and
determining a regional distribution of WMH based on an anatomical atlas and the total volume.

18. The system of claim 17 , wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.

19. The system of claim 17 , wherein the selecting is based on image analysis based on at least one of image brightness information, image historic information, image degradation information, or imaging machine information.

20. The system of claim 17 , wherein the method further comprising:
editing the imaging data based on the analyzing.

21. A non-transitory computer-readable storage medium storing a set of instructions for execution via a processing circuit to implement a method comprising:
selecting, via a computer, an intensity threshold value;
defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
determining, via the computer, a total volume of the voxels based on the extracting; and
determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.

Assignees

• Brickman Adam M
• Muraskin Jordan
• Provenzano Frank A
• Narkhede Atul
• Univ Columbia

Inventors

• Brickman Adam M
• Muraskin Jordan
• Provenzano Frank A
• Narkhede Atul

Classifications

• A61B2576/026

  for the brain · CPC title

• A61B5/7425

  Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image · CPC title

• A61B5/16

  Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state} · CPC title

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• G06T2207/20076

  Probabilistic image processing · CPC title