Confocal microscope, system and method therefor

Patent metadata

Field	Value
Publication number	US-9864190-B2
Application number	US-201213403614-A
Country	US
Kind code	B2
Filing date	Feb 23, 2012
Priority date	Feb 24, 2011
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.

First claim

What is claimed is:

1. An apparatus comprising:
a first scanning mirror arrangement facing a first direction and configured and arranged to direct source light and image light in two paths, the first scanning mirror arrangement having a first axis of movement and a second axis of movement; and
a second scanning mirror arrangement facing a second direction that is different than the first direction and having a third axis of movement that is different than the first and second axes of movement and orthogonal to a target, the second scanning mirror arrangement configured and arranged to translate along the third axis and direct the image light from the target to the first scanning mirror arrangement, the first and second scanning mirror arrangements having different scanning axes and being cooperatively arranged to
scan the source light directed from the first scanning mirror arrangement and via the second scanning mirror arrangement to target locations with at least two degrees of freedom, and
direct image light from the target locations via the second scanning mirror arrangement to the first scanning mirror arrangement, the source light and image light being passed between the first and second scanning mirror arrangements in collimated beams, whereby the target location is moved via the cooperative movement of the first and second scanning mirror arrangements.

2. The apparatus of claim 1 , wherein the first and second scanning mirror arrangements respectively include first and second parabolic mirrors that are fixed relative to and facing one another, and respectively include first and second scanning mirrors facing away from one another, the second scanning mirror having an axis of movement that is orthogonal to the target, in which the mirrors collectively provide three degrees of freedom for adjusting the target location to which the source light is directed along the three axes by
scanning source light from the first scanning mirror to the first parabolic mirror, from the first parabolic mirror to the second parabolic mirror, from the second parabolic minor to the second scanning mirror, and from the second scanning mirror to the target,
while scanning the source light, directing image light from the target to the second parabolic mirror, from the second parabolic mirror to the first parabolic mirror, from the first parabolic mirror to the first scanning mirror, and from the first scanning mirror to a detector, and
wherein the source light and image light are passed between the first and second parabolic mirrors along parallel paths, and the first and second scanning mirrors are configured and arranged with one another to cooperatively rotate along parallel axes for concurrently scanning the source light and detecting the image light.

3. The apparatus of claim 1 , wherein the first axis of movement and the second axis of movement are torsional axes, and the third axis of movement is a piston motion axis, the apparatus further including beam-shaping optics configured to direct light between the first and second scanning mirror arrangements, and the second scanning mirror arrangement configured and arranged to vary a working distance to the target by moving along the third axis of movement.

4. The apparatus of claim 3 , wherein the beam-shaping optics are configured and arranged to collimate light for passing between the first and second scanning mirror arrangements.

5. The apparatus of claim 1 , further including a multimodal end-piece interface configured and arranged to
direct and receive the source and image light between the target locations and the second scanning mirror arrangement to provide image information in a first modality, and
acquire information from the target location in a second modality.

6. The apparatus of claim 5 , wherein the multimodal end-piece interface is configured and arranged to direct and receive the source and image light while acquiring the information in a second modality, to concurrently provide information for two modalities.

7. The apparatus of claim 5 , wherein the first and second scanning mirror arrangements are configured and arranged to actuate in different manners based upon a type of end-piece connected to the multimodal end-piece interface.

8. The apparatus of claim 1 , wherein at least one of the scanning mirror arrangements includes a mirror having two reflective sections that are respectively configured and arranged to simultaneously deflect two beams of the light to focus the two beams to the target.

9. A multimodal endoscopic apparatus comprising:
a scan-engine module including
a first scanning mirror arrangement facing a first direction and configured and arranged to direct source light and image light in two paths, and including a first scanning mirror having two axes of movement,
a second scanning mirror arrangement facing a second direction that is different than the first direction and cooperatively arranged with the first scanning mirror arrangement to direct light received from the first scanning mirror arrangement to a target, and direct image light from the target to the first scanning mirror arrangement, the second scanning mirror arrangement including a second scanning mirror having a third axis of movement that is orthogonal to the target and being configured to translate along the third axis, the first and second scanning mirror arrangements being configured and arranged to collectively provide three degrees of freedom for scanning the target, and
mirrors configured and arranged to direct light along parallel and separate paths between the first and second scanning mirror arrangements; and

a multimodal end-piece interface configured and arranged to interface with a plurality of different end pieces to facilitate acquisition of information for multiple modalities.

10. The apparatus of claim 9 , wherein the scan-engine module and multimodal end-piece interface are configured and arranged to concurrently acquire light-based information and at least one additional type of information to facilitate multiple modalities.

11. The apparatus of claim 9 , wherein the first and second directions are opposite one another, and the scan-engine module and multimodal end-piece interface are configured and arranged to concurrently acquire at least two sets of information including light-based information, to provide information for one of the multiple modalities.

12. The apparatus of claim 9 , wherein the scan-engine module is configured and arranged to actuate the scanning mirror arrangements in different manners respectively based upon a type of end-piece connected to the multimodal end-piece interface.

13. The apparatus of claim 9 , further including a GRIN relay lens in the optical path of the light and configured and arranged to couple with different types of end-pieces connected to the multimodal end-piece interface.

14. The apparatus of claim 9 , further including a micromachined ultrasonic transducer configured and arranged to apply and detect ultrasonic waves to characterize the target.

15. The apparatus of claim 9 , wherein the first and second scanning mirror arrangements are configured and arranged to scan light about different scanning axes to collectively provide three degrees of freedom for scanning the target by scanning light to target locations within tissue along three different axes.

16. The apparatus of claim 9 , wherein at least one of the scanning mirror arrangements includes a mirror having two reflective sections that are respectively configured and arranged to simultaneously deflect two beams of the light to focus the two

Assignees

• Mandella Michael
• Kino Gordon S
• Contag Christopher H
• Solgaard Olav
• Khuri-Yakub Butrus
• Oralkan Omer
• Jeong Jae-Woong
• Cristman Paul
• Liu Jonathan T C
• Ra Hyejun
• Hwang Jae Eun
• Univ Leland Stanford Junior

Inventors

• Mandella Michael
• Kino Gordon S
• Contag Christopher H
• Solgaard Olav
• Khuri-Yakub Butrus
• Oralkan Omer
• Jeong Jae-Woong
• Cristman Paul
• Liu Jonathan T C
• Ra Hyejun
• Hwang Jae Eun

Classifications

• G02B17/0808

  on-axis systems with at least one of the mirrors having a central aperture · CPC title

• G02B23/26

  using light guides {(for illumination G02B23/2469)} · CPC title

• A61B5/0068

  Confocal scanning · CPC title

• G02B26/101 Primary

  with both horizontal and vertical deflecting means, e.g. raster or XY scanners (colour television using laser beams scanning a display screen H04N9/3129) · CPC title

• A61B1/043

  for fluorescence imaging · CPC title