Apparatus and method for conditioning and reorienting components on an electrophysiology measurement system

Patent metadata

Field	Value
Publication number	US-9863906-B2
Application number	US-201514887696-A
Country	US
Kind code	B2
Filing date	Oct 20, 2015
Priority date	Aug 7, 2012
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

An apparatus for automatically conditioning a patch plate and a plenum of an electrophysiology measurement system is provided. An arm is linearly movable between a non-operative position and an operative position. An end effector mounted to one side of the arm is configured to condition the patch plate. Another end effector mounted to an opposite side of the arm is configured to condition the plenum. A linear actuator is coupled to the arm and is configured to drive movement of the arm between the operative position and the non-operative position. When the arm is positioned in the operative position, the arm is situated between the patch plate and the plenum.

First claim

What is claimed is:

1. An apparatus for automatically reorienting a patch plate of an electrophysiology measurement system, the apparatus comprising:
a linearly movable platform configured to support the patch plate and comprising a cornering arm configured to pivot into contact with the patch plate;
a frame having an opening sized and shaped to permit movement of the platform through the opening;
an elevating arm mounted to the platform wherein the elevating arm is configured to move the platform through the opening;
a linear actuator mounted to the elevating arm wherein the linear actuator is configured to drive movement of the elevating arm; and
at least one cornering cam mounted proximate to at least one interior edge of the opening and configured to engage the cornering arm such that the cornering arm pivots toward the platform and pushes the patch plate into a reference corner of the platform.

2. The apparatus of claim 1 wherein a cam-engagement end of the cornering arm engages a chamfer of the at least one cornering cam when the platform moves through the opening of the frame such that:
when the platform is lowered into the opening of the frame, the cam-engagement end of the cornering arm pivots toward the platform and a plate-engagement end of the cornering arm pivots away from the platform; and
when the platform is raised out of the opening of the frame, the cam-engagement end of the cornering arm pivots away from the platform and the plate-engagement end of the cornering arm pivots toward the platform and pushes the patch plate supported on the platform into the reference corner of the platform.

3. The apparatus of claim 1 further comprising a rotary actuator configured to drive rotation of the platform about a central axis such that the patch plate is reoriented relative to the frame.

4. The apparatus of claim 3 wherein:
the opening is shaped to receive the platform in a portrait orientation or a landscape orientation relative to the frame;
the at least one interior edge comprises at least four interior edges; and
the at least one cornering cam comprises at least four cornering cams respectively attached to the at least four interior edges such that at least four cam-engagement ends of the at least four cornering arms of the platform engage the at least four cornering cams when the platform moves through the opening in the portrait orientation or the landscape orientation.

5. The apparatus of claim 1 further comprising a plurality of support columns respectively located at a plurality of interior corners of the opening and positioned to engage respective corners of the patch plate supported on the platform such that, when the platform is lowered through the opening and below the frame, the platform deposits the patch plate onto the support columns.

6. A method for automatically reorienting a patch plate of the electrophysiology measurement system of claim 1 having the linearly movable platform, the cornering arm, the frame having the opening with the at least one interior edge, the elevating arm, the linear actuator, and the at least one cornering cam, the method comprising:
lowering the platform having the cornering arm into the opening of the frame such that, when the platform is positioned within the opening, a cam-engagement end of the cornering arm is pivoted toward the platform and a plate-engagement end of the cornering arm is pivoted away from the platform;
depositing the patch plate on the platform; and
raising the platform out of the opening such that the cam-engagement end of the cornering arm pivots away from the platform and the plate-engagement end of the cornering arm pivots toward the platform and pushes the patch plate into a reference corner of the platform.

7. The method of claim 6 , wherein the cam-engagement end of the cornering arm engages a chamfer of the at least one cornering cam located proximate to the at least one interior edge of the opening such that, when the platform is raised out of the opening of the frame, the cam-engagement end of the cornering arm moves up along the chamfer of the at least one cornering cam as the cam-engagement end pivots away from the platform.

8. The method of claim 6 , further comprising rotating the platform about a central axis such that the patch plate supported on the platform is reoriented relative to the frame.

9. The method of claim 8 wherein:
the opening of the frame is shaped to receive the platform in a portrait orientation or a landscape orientation relative to the frame;
the at least one cornering cam comprises at least four cornering cams;
the at least one interior edge comprises at least four interior edges; and
the at least four cornering cams are respectively located proximate to the at least four interior edges of the opening such that at least four cam-engagement ends of at least four respective cornering arms of the platform respectively engage the at least four cornering cams when the platform moves through the opening in the portrait orientation or the landscape orientation.

10. The method of claim 6 , further comprising lowering the platform through the opening and below the frame such that the platform deposits the patch plate onto one or more support columns located at one or more respective interior corners of the opening of the frame wherein the one or more support columns are positioned to engage the one or more respective corners of the patch plate.

Assignees

• Molecular Devices Llc

Inventors

• Lee Lawrence
• Owens Windsor

Classifications

• B01J19/08

  Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor (application of shock waves B01J3/08) · CPC title

• G01N27/283 Primary

  Means for supporting or introducing electrochemical probes · CPC title

• B01L9/523

  for multisample carriers, e.g. used for microtitration plates · CPC title

• G01N27/327

  Biochemical electrodes {, e.g. electrical or mechanical details for in vitro measurements} · CPC title

• G01N33/48728 Primary

  Investigating individual cells, e.g. by patch clamp, voltage clamp (investigating individual particles in general G01N15/10) · CPC title