Salts of a pim kinase inhibitor

Patent metadata

Field	Value
Publication number	US-9862705-B2
Application number	US-201615260695-A
Country	US
Kind code	B2
Filing date	Sep 9, 2016
Priority date	Sep 9, 2015
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.

First claim

What is claimed is:

1. A salt having the formula:

2. The salt of claim 1 wherein the salt is crystalline.

3. The salt of claim 2 which is hydrated.

4. The salt of claim 3 which is a hemihydrate.

5. A pharmaceutical composition comprising the salt of claim 1 and at least one pharmaceutically acceptable carrier.

6. A solid oral dosage form comprising the pharmaceutical composition of claim 5 .

7. A pharmaceutical composition comprising the salt of claim 2 and at least one pharmaceutically acceptable carrier.

8. A solid oral dosage form comprising the pharmaceutical composition of claim 7 .

9. A pharmaceutical composition comprising the salt of claim 3 and at least one pharmaceutically acceptable carrier.

10. A solid oral dosage form comprising the pharmaceutical composition of claim 9 .

11. A pharmaceutical composition comprising the salt of claim 4 and at least one pharmaceutically acceptable carrier.

12. A solid oral dosage form comprising the pharmaceutical composition of claim 11 .

Assignees

• Incyte Corp

Inventors

• Jia Zhongjiang
• Cao Ganfeng
• Pan Yongchun
• Sharief Vaqar
• Zhou Jiacheng

Classifications

• A61P35/04

  specific for metastasis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title