Compounds and methods of treating cancer

Patent metadata

Field	Value
Publication number	US-9862693-B2
Application number	US-201414566055-A
Country	US
Kind code	B2
Filing date	Dec 10, 2014
Priority date	Jun 11, 2012
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.

First claim

What is claimed is:

1. A compound having the formula:

wherein;
L 1 and L 2 are independently a bond or —NH—C(NH)—;
R 1 is —NR 1A R 1B , wherein R 1A and R 1B are independently substituted or unsubstituted alkyl and are joined together to form a substituted or unsubstituted pyrrolidinyl, or an unsubstituted piperidinyl;
R 2 is —NR 2A R 2B , wherein R 2A and R 2B are independently substituted or unsubstituted alkyl and are joined together to form a substituted or unsubstituted pyrrolidinyl; and
R 3 is hydrogen or unsubstituted C 1 -C 5 alkyl.

2. The compound of claim 1 , wherein L 1 and L 2 are bonds and R 3 is hydrogen.

3. The compound of claim 2 , wherein R 1A and R 1B are joined together to form an unsubstituted piperidinyl.

4. The compound of claim 1 , wherein said compound has the formula:

5. The compound of claim 4 , wherein R 3 is hydrogen.

6. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound having formula:

wherein;
L 1 and L 2 are independently a bond or —NH—C(NH)—;
R 1 is —NR 1A R 1B , wherein R 1A and R 1B are independently substituted or unsubstituted alkyl and are joined together to form a substituted or unsubstituted pyrrolidinyl, or an unsubstituted piperidinyl;
R 2 is —NR 2A R 2B , wherein R 2A and R 2B are independently substituted or unsubstituted alkyl and are joined together to form a substituted or unsubstituted pyrrolidinyl; and
R 3 is hydrogen or unsubstituted C 1 -C 5 alkyl.

7. The pharmaceutical composition of claim 4 , wherein said compound has the formula:

Assignees

• Univ California

Inventors

• Pietras Richard J
• Jung Michael E
• Marquez-Garban Diana C
• Deng Gang

Classifications

• C07D401/12

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K31/155

  Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C07D213/78

  Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

• C07C279/26

  X and Y being nitrogen atoms, i.e. biguanides · CPC title