Closed loop control of microfluidic systems
US-2024293817-A1 · Sep 5, 2024 · US
US9861985B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9861985-B2 |
| Application number | US-201113222887-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 31, 2011 |
| Priority date | Aug 31, 2010 |
| Publication date | Jan 9, 2018 |
| Grant date | Jan 9, 2018 |
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The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify the positions of slugs.
Opening claim text (preview).
What is claimed is: 1. A method for controlling the position of a slug in a microfluidic device, comprising: (a) providing a slug in a microfluidic channel of the microfluidic device; (b) exciting a fluorescent dye in said slug; (c) acquiring an image including a portion of the microfluidic channel having the slug emitting the fluorescence and a portion of the microfluidic channel without the slug; (d) processing intensity profile data from a region of interest in said image…
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