Amine-functionalized polymeric compositions for medical devices

Patent metadata

Field	Value
Publication number	US-9861723-B2
Application number	US-201715491228-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Oct 24, 2012
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

First claim

What is claimed is:

1. A wound dressing comprising an amine-functionalized polymer foam and a biologically active agent covalently attached to an amine group on the polymer foam.

2. The wound dressing of claim 1 , wherein the biologically active agent is attached to the foam through an adapter.

3. The wound dressing of claim 1 , wherein the biologically active agent is a polypeptide.

4. The wound dressing of claim 3 , wherein the polypeptide is selected from the group consisting of gelatin, collagen, albumin, an enzyme, growth factor, chemokine, cytokine, and a polypeptide that binds to any of them.

5. The wound dressing of claim 4 , wherein the polypeptide is an enzyme selected from a protease, hydrolase, lyase, ligase, isomerase, transferase, oxidase, reductase, oxidoreductase, synthase, polymerase, kinase, and phosphatase.

6. The wound dressing of claim 1 , comprising a polyurethane foam.

7. The wound dressing of claim 6 , comprising an open cell foam.

8. The wound dressing of claim 1 , wherein the amine-functionalized polymer foam comprises a polyurethane polymer copolymerized with neomycin.

9. The wound dressing of claim 1 , wherein the biologically active agent is directly attached to the functionalized polymer foam.

10. The wound dressing of claim 2 , wherein the adapter is an amine to amine crosslinker.

11. The wound dressing of claim 10 , wherein the amine-to-amine crosslinker is selected from malondialdehyde, succinaldehyde, phthalaldehyde, glutaraldehyde, and glyoxal.

12. The wound dressing of claim 11 , wherein the crosslinker is glutaraldehyde.

13. The wound dressing of claim 2 , wherein the adapter is cleavable.

14. The wound dressing of claim 7 , wherein the material comprises a foam that is a reticulated open-celled foam.

15. A method for treating a wound site, comprising:
applying a wound dressing according to claim 1 to a wound site; and
applying negative pressure to the wound site.

16. The method of claim 15 , further comprising applying an instillation solution to the wound site.

17. The method of claim 15 , wherein the biologically active agent comprises a polypeptide.

18. The method of claim 16 , wherein the instillation solution includes one or more agents that modulate a release of the biologically active agent.

19. The wound dressing of claim 1 , wherein the biologically active agent comprises a debridement enzyme.

20. The wound dressing according to claim 19 , wherein the biologically active agent is bromelain.

21. The wound dressing according to claim 19 , wherein the biologically active agent is papain.

22. The wound dressing according to claim 19 , wherein the biologically active agent is trypsin.

23. The wound dressing according to claim 19 , wherein the biologically active agent is collagenase.

Assignees

• Kci Licensing Inc

Inventors

• Hanson Douglas Philip
• Courage James

Classifications

• C08J9/00

  Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof (mechanical aspects of shaping of plastics or substances in a plastic state for the production of porous or cellular articles B29C) · CPC title

• A61F13/00063

  comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00) · CPC title

• A61L26/0085

  Porous materials, e.g. foams or sponges · CPC title

• A61L2300/406

  Antibiotics · CPC title

• A61F13/00017

  Human Necessities · mapped topic