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Coriolus versicolor extracts, methods of isolating biologically-active compounds, and uses thereof
US9861604B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9861604-B2 |
| Application number | US-201414305811-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 16, 2014 |
| Priority date | Apr 11, 2012 |
| Publication date | Jan 9, 2018 |
| Grant date | Jan 9, 2018 |
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- Title
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Abstract
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The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor . In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor , as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.
First claim
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We claim: 1. A method for treating cancer or a tumor, comprising administering, to a subject in need of such treatment, an effective amount of a composition comprising 9-oxo-10E, 12E-octadecadienoic acid methyl ester, or a salt thereof, wherein the cancer or tumor is selected from the group consisting of glioblastoma, breast carcinoma, and lung carcinoma. 2. The method of claim 1 , wherein the subject is a human. 3. A method for treating cancer or a tumor, comprising administering, to a subject in need of such treatment, an effective amount of a composition comprising 9-oxo-10E, 12E-octadecadienoic acid methyl ester, or a salt thereof, wherein the cancer is metastatic cancer and the administration of the composition is used to reduce cancer metastasis. 4. The method of claim 3 , wherein the subject is a human. 5. The method according to claim 1 , wherein the compound inhibits the expression of MMP3. 6. The method according to claim 1 , wherein the compound reduces TNF-α, wherein the compound reduces TNF-α production in tumor cells.
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Classifications
specific for metastasis · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Antineoplastic agents · CPC title
specific for leukemia · CPC title
Recycling of unreacted starting or intermediate materials · CPC title
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- What does patent US9861604B2 cover?
- The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor . In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor , as well as 9-KODE methyl ester and related compounds. In a…
- Who is the assignee on this patent?
- Purapharm Company Ltd, Versitech Ltd, Lau Maureen, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/231. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 09 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).