Injector apparatus and method for drug delivery

Patent metadata

Field	Value
Publication number	US-9861521-B2
Application number	US-201514713505-A
Country	US
Kind code	B2
Filing date	May 15, 2015
Priority date	Aug 5, 2010
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

First claim

What is claimed is:

1. A system for injecting a therapeutic agent into an ocular implant, the system comprising:
an injection lumen configured to provide a pathway for injecting a therapeutic agent into the ocular implant using positive pressure applied through the injection lumen;
an outlet lumen configured to provide a pathway through which a first amount of pre-existing fluid in the ocular implant exits the ocular implant as therapeutic agent is injected into the ocular implant through the injection lumen;
a receiver chamber fluidly coupled to the outlet lumen, the receiver chamber configured to receive fluid that exits the ocular implant via the outlet lumen;
wherein injection of the therapeutic agent into the ocular implant via the injection lumen upon application of the positive pressure displaces the first amount of pre-existing fluid in the ocular implant into the receiver chamber via the outlet lumen.

2. A system as in claim 1 , further comprising a needle that defines the injection lumen.

3. A system as in claim 2 , wherein an opening near the end of the needle permits fluid to pass from the injection lumen into the ocular implant.

4. A system as in claim 2 , further comprising a sheath positioned at least partially around an outer surface of the needle such that the sheath and the needle are concentric so as to form the outlet lumen between an inner surface of the sheath and the outer surface of the needle.

5. A system as in claim 4 , wherein the sheath forms at least one opening through which fluid can pass from the implant into the outlet lumen.

6. A system as in claim 5 , wherein the opening is between a distal-most end of the sheath and an outer surface of the needle.

7. A system as in claim 4 , wherein the opening near the end of the needle is distal of an opening into the outlet lumen.

8. A system as in claim 4 , wherein a distal tip of the sheath tapers such that at least a portion of the distal tip of the sheath contacts an outer surface of the needle.

9. A system as in claim 4 , wherein at least a portion of a distal tip of the sheath is spaced from an outer surface of the needle.

10. A system as in claim 1 , wherein the outlet lumen and the injection lumen are concentrically positioned relative to one another.

11. A system as in claim 1 , further comprising a source chamber fluidly coupled to the injection lumen, the source chamber providing a source of therapeutic agent for injecting into the ocular implant via the injection lumen.

12. A system as in claim 11 , wherein the source chamber is removably attached to the injection lumen.

13. A system as in claim 11 , wherein the source chamber is loaded with a therapeutic agent.

14. A system as in claim 11 , wherein the source chamber is part of a syringe that attaches to the injection lumen.

15. A system as in claim 1 , further comprising a hub configured to removably receive a syringe that is configured to fluidly couple to the injection lumen.

16. A system as in claim 1 , wherein the system further comprising a stop, the stop configured to limit a depth of insertion of the injection lumen into the ocular implant.

17. A system as in claim 1 , wherein the injection lumen and outlet lumen are sized to insert through a resealable septum of the ocular implant in a resealable manner.

18. A system as in claim 17 , wherein the injection lumen is a lumen of a needle that is 33 gauge.

19. A system as in claim 18 , wherein the outlet lumen is a lumen of a sheath that is 30 gauge.

20. A system as in claim 7 , wherein the first amount of pre-existing fluid is displaced from the ocular implant and mixing with the therapeutic agent injected via the injection lumen is substantially inhibited.

Assignees

• Forsight Vision4 Inc

Inventors

• De Juan Jr Eugene
• Alster Yair
• Farinas Kathleen Cogan
• Macfarlane K Angela
• Reich Cary J
• Campbell Randolph E
• Doud Darren
• Erickson Signe
• Barrett Mike
• Batten David
• Skieller Christina
• Stine Greg

Classifications

• A61M2039/027

  having a particular valve, seal or septum · CPC title

• A61M39/0208

  Subcutaneous access sites for injecting or removing fluids (transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276) · CPC title

• A61M5/14276

  specially adapted for implantation · CPC title

• A61F9/0017 Primary

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61M39/0247

  Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body (peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053) · CPC title