Method for producing micro plasma with biocompatibility

Patent metadata

Field	Value
Publication number	US-9855441-B2
Application number	US-201615067235-A
Country	US
Kind code	B2
Filing date	Mar 11, 2016
Priority date	Mar 31, 2014
Publication date	Jan 2, 2018
Grant date	Jan 2, 2018

Abstract

The object of the present invention is to provide a method for producing a micro-plasma with biocompatibility. The produced micro-plasma is a low temperature, adjustable micro-plasma with low energy consumption. The method provides a device comprising a first gas storage unit, a second gas storage unit, a unit for producing the micro-plasma, and a power supply unit.

First claim

What is claimed is:

1. A method for wound treatment, comprising the following steps:
(A) providing a device comprising a first gas storage unit, a second gas storage unit, a micro-plasma generation unit, a power supply unit, and a temperature measurement system for measuring an average temperature of the micro-plasma, which is within a range of 34-40° C.;
(B) introducing helium or argon stored in the first gas storage unit into the micro-plasma generation unit to excite a micro-plasma to a steady state within a predetermined time;
(C) introducing oxygen or nitrogen stored in the second gas storage unit into the micro-plasma generation unit so as to produce a micro-plasma containing micro-plasma excited species; and
(D) contacting the wound with the micro-plasma excited species;
wherein an addition ratio of the nitrogen is within a range of 0.1-2% and an addition ratio of the oxygen is within a range of 0.1-5%; and
wherein the excitation power used for producing the micro-plasma is within a range of 1-30 W.

2. The method of claim 1 , wherein the micro-plasma generation unit of the step (A) comprises a capillary tube in which the micro-plasma is excited to produce a low temperature micro-plasma.

3. The method of claim 1 , wherein the first gas storage unit of the step (A) further comprises a gas flow monitor for showing the steady state of the excited micro-plasma.

4. The method of claim 1 , wherein a flow rate of helium or argon is 1-10 Standard Liters per Minute (SLM).

5. The method of claim 4 , wherein the flow rate of helium or argon is within a range of 1-5 SLM.

6. The method of claim 1 , wherein the addition ratio of the oxygen is within a range of 0.1-2%.

7. The method of claim 1 , wherein the addition ratio of the nitrogen is within a range of 0.1-1%.

8. The method of claim 1 , wherein a processing time of the micro-plasma is within a range of 5-300 seconds.

9. The method of claim 1 , wherein the excitation power is within a range of 15-25 W.

10. The method of claim 1 , wherein the device of the step (A) further comprises a micro-plasma emission spectrometer for quantitatively or qualitatively detecting a type of the micro-plasma excited species.

11. The method of claim 1 , wherein the micro-plasma excited species is reactive oxygen species (ROS) or reactive nitrogen species (RNS).

12. The method of claim 1 , wherein contacting the wound is performed in a subject in need thereof.

13. The method of claim 12 , wherein the subject is a human.

14. The method of claim 12 , wherein the step (C) further comprises setting a working distance between the subject and the micro-plasma generation unit.

15. The method of making claim 14 , wherein the working distance is within a range of 1-12 mm.

Assignees

• Univ Nat Cheng Kung

Inventors

• Liao Jiunn-Der
• Shao Pei-Lin

Classifications

• H05H2245/34

  Skin treatments, e.g. disinfection or wound treatment · CPC title

• A61N1/44 Primary

  Applying ionised fluids {(ion generators H01J37/00)} · CPC title

• H01J37/32981

  Gas analysis · CPC title

• H05H2245/122

  Electricity · mapped topic

• H01J37/32449

  Gas control, e.g. control of the gas flow · CPC title