Active implantable medical device with automatic optimization of the configuration of a multi-electrode stimulation lead

Patent metadata

Field	Value
Publication number	US-9855428-B2
Application number	US-201615224328-A
Country	US
Kind code	B2
Filing date	Jul 29, 2016
Priority date	May 19, 2014
Publication date	Jan 2, 2018
Grant date	Jan 2, 2018

Abstract

A device includes a pulse generator coupled to a neurostimulation lead placed around the nerve and a set of electrodes individually connected to the generator by a splitter circuit controlled to preferentially stimulate certain regions of the nerve relative to other regions. The device performing an iterative search of an optimal configuration operating by selection of a plurality of different stimulation configurations, storing of a cardiac physiological parameter measured for each selected stimulation configuration, and designation as optimal stimulation configuration of the one of said selected different stimulation configurations, depending on at least the stored values of the physiological parameter measured for different electrode configurations.

First claim

What is claimed is:

1. A method for configuration of an implantable neurostimulation device comprising:
recording one or more physiological parameters using a sensing lead and a sensing electrode of the implantable neurostimulation device;
setting, by a control circuit of the implantable neurostimulation device, a first stimulation configuration with at least one of a first energy, a first pulse amplitude, or a first number of pulses;
determining, by the control circuit, if conditions of stability of a patient's condition are met, and if so, delivering the first stimulation to a nerve by a stimulation lead; and
repeating delivery of the first stimulation while testing a plurality of configurations of a set of stimulation electrodes;
wherein testing the plurality of configurations of the set of stimulation electrodes comprises:
storing the measured physiological parameters of each of the plurality of configurations;
changing, by the control circuit, the configuration of the set of stimulation electrodes; and
determining a selected configuration that produces a best calculated effect on the recorded one or more physiological parameters.

2. The method of claim 1 , further comprising:
determining, by the control circuit, if the calculated effect on the recorded on or more physiological parameters reaches a preset target value, and if it does not:
modifying at least one of an amplitude or a number of stimulation pulses; and
repeating the modified stimulation while testing the plurality of configurations of the set of stimulation electrodes.

3. The method of claim 2 , further comprising:
determining, after trying all possible configurations, that the preset target value cannot be achieved;
stopping the configuration method; and
selecting a default standard configuration for stimulation.

4. The method of claim 1 , wherein the first stimulation configuration comprises a stimulation amplitude of 1 mA and one pulse.

5. The method of claim 1 , further comprising selecting the selected configuration for stimulation that includes a least number of cathodes and consumes less power, when it is determined that more than one stimulation configuration produces the same calculated effect.

6. The method of claim 1 , further comprising maintaining one configuration of the set of stimulation electrodes, and determining an impact of a change in a current distribution between the different electrodes, and selecting the selected configuration for stimulation based on the electrode configuration and the current distribution.

7. The method of claim 1 , further comprising detecting, simultaneously with the measurement of the physiological parameter, an occurrence of an adverse effect, and selecting the selected configuration for stimulation based on an electrode configuration and the configuration that produces fewest adverse effects.

Assignees

• Sorin Crm Sas
• Inria—Institut National De Rech En Informatique Et En Automatique

Inventors

• Henry Christine
• Laporte-Duchemin Laure
• Andreu David
• Azevedo-Coste Christine
• Guiraud David
• Maciejasz Pawel
• Rossel Olivier

Classifications

• A61N1/36185

  Selection of the electrode configuration · CPC title

• A61N1/0551 Primary

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/36114

  Cardiac control, e.g. by vagal stimulation (stimulating the heart A61N1/362) · CPC title

• A61N1/36139 Primary

  with automatic adjustment · CPC title

• A61N1/36057

  adapted for stimulating afferent nerves · CPC title