Orexin receptor antagonists

Patent metadata

Field	Value
Publication number	US-9850237-B2
Application number	US-201715409246-A
Country	US
Kind code	B2
Filing date	Jan 18, 2017
Priority date	Jul 3, 2012
Publication date	Dec 26, 2017
Grant date	Dec 26, 2017

Abstract

The disclosures herein relate to novel compounds of formula

wherein W, X and Y 1 , Y 2 , Y 3 and Y 4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

First claim

The invention claimed is:

1. A compound of formula

Wherein:
(i) Y 1 , Y 2 , Y 3 and Y 4 are independently a carbon or a nitrogen atom, wherein no more than one of Y 1 , Y 2 , Y 3 and Y 4 is a nitrogen atom;
(ii) W is selected from:

and
(iii) X is selected from:

2. The compound of claim 1 , wherein Y 1 is nitrogen.

3. The compound of claim 1 , wherein Y 4 is N.

4. The compound of claim 1 , wherein W is

5. The compound of claim 1 , wherein X is

6. The compound of claim 1 , wherein the compound is 2-(5,6-Dimethoxypyridin-3-yl)-4-(2,4,6-trifluorobenzyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide.

7. A pharmaceutical composition comprising the compound of claim 1 .

8. A method of treating, ameliorating, controlling or reducing the risk of a neurological or psychiatric disorder in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1 , wherein the neurological or psychiatric disorder is a movement disorder, an anxiety disorder, a panic disorder, a cognitive impairment or Alzheimer's disease.

9. A method of treating insomnia in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1 .

10. A method of treating migraine, cluster headache or other headache disorders in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1 .

11. A method of treating obesity in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1 .

12. A method of treating a binge eating disorder, a compulsive disorder or an impulse control disorder in a subject in need thereof, comprising administering to the subject an effective amount of the compound of claim 1 .

Assignees

• Heptares Therapeutics Ltd

Inventors

• Congreve Miles Stuart
• Christopher John Andrew
• Tehan Benjamin Gerald
• Klair Sukhbinder Singh
• Aves Sarah Joanne

Classifications

• A61P39/02

  Antidotes · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• A61P25/24

  Antidepressants · CPC title