Compositions and methods for preventing and treating diseases and environmentally induced health disorders

Patent metadata

Field	Value
Publication number	US-9849153-B2
Application number	US-201615235384-A
Country	US
Kind code	B2
Filing date	Aug 12, 2016
Priority date	Dec 24, 2009
Publication date	Dec 26, 2017
Grant date	Dec 26, 2017

Abstract

Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, such as Onaway, Russet Burbank, Purple Valley or Bora Valley cultivars. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.

First claim

What is claimed is:

1. A dietary supplement or additive for reducing body weight gain and/or controlling blood glucose levels comprising a composition enriched in ferulic acid, caffeic acid, chlorogenic acids, anthocyanins, ascorbic acid, and rutin, or an isomer or derivative thereof having antioxidant and/or anti-inflammatory activity, said composition comprising an extract or fraction of an Onaway potato cultivar and a Russet Burbank potato cultivar wherein the extract or fraction comprises said chlorogenic acids and said ferulic acid in a proportion ranging between 25:1 and 35:1 by weight.

2. The dietary supplement or additive of claim 1 , wherein said composition further comprises an extract or fraction of at least one of a Bora Valley or Purple Valley potato cultivar, or a combination thereof.

3. The dietary supplement or additive of claim 1 , prepared as an oral supplement, a functional food, or a food/feed additive.

4. The dietary supplement or additive of claim 1 , wherein said extract or fraction is derived from the potato skin, pith, or cortex, or a combination thereof.

5. The dietary supplement or additive of claim 1 , formulated as a pharmaceutical or nutraceutical composition and further comprising one or more acceptable carriers or excipients.

6. The dietary supplement or additive of claim 1 , wherein the extract or fraction is obtained from a fresh source of at least one potato cultivar.

7. The dietary supplement or additive of claim 1 , wherein the extract or fraction is obtained from the source of at least one potato cultivar within 2 months post-harvest.

8. The dietary supplement or additive of claim 1 , wherein the extract or fraction is obtained from the source of the potato cultivar within 1 month post-harvest.

9. The dietary supplement or additive of claim 1 , wherein the source of the potato cultivar has been treated to induce hormesis before or after harvesting, or during the storage interval of the source of at least one potato cultivar, and the treatment increases the level of one or more of ferulic acid, caffeic acid, chlorogenic acids, anthocyanins, ascorbic acid, rutin, or isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity in the source of at least one potato cultivar.

10. The dietary supplement or additive of claim 9 , wherein the treatment to induce hormesis is selected from the group consisting of: treatment with relatively high or low temperature air or water; treatment with an excess of one or more minerals; partial to severe starvation of one or more minerals; treatment with ionizing radiation; treatment with one or more oxidizing agents; wounding; and treatment with one or more phytochemicals.

11. A functional food comprising a food enriched with a dietary supplement or additive according to claim 1 .

Assignees

• The Royal Institution For The Advancement Of Learning/Mcgill Univ

Inventors

• Kubow Stanley
• Donnelly Danielle
• Piccolomini Andre
• Agellon Luis

Classifications

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K36/81 Primary

  Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed · CPC title

• A61K31/375

  Ascorbic acid, i.e. vitamin C; Salts thereof · CPC title

• A61K31/7048

  having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title