Active formulation for use in feed products

Patent metadata

Field	Value
Publication number	US-9849105-B2
Application number	US-201214131216-A
Country	US
Kind code	B2
Filing date	Jul 3, 2012
Priority date	Jul 8, 2011
Publication date	Dec 26, 2017
Grant date	Dec 26, 2017

Abstract

Invention pertains to a free-flowing particulate powder including 2-90 wt. % of an active compound on a carrier, wherein the carrier has a D(v,0.1) of at least 100 microns, with the active compound being selected from lactylate in accordance with formula (1), Formula (1): R2-COO—[—CH(CH3)-COO]n-R1 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, a glycolylate of formula (2), Formula (2): R2-COO—[—CH2-COO]n-R1 or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof a lactate ester of formula (3), Formula (3): HO—CH(CH3)-COO—R2 and/or a glycolic acid ester of formula (4), Formula (4): HO—CH2-COO—R2 wherein in the above formulae R1 is selected from H, n stands for an integer with a value of 1-10, and R2 stands for a C1-C35 alkyl or alkenyl chain which may be branched or unbranched. The powder allows easy provision of the active compound to feed compositions.

First claim

The invention claimed is:

1. Free-flowing particulate powder comprising 10-90 wt. % of an active compound on a porous carrier and having a Hausner ratio of at most 1.25, wherein:
the carrier has a D(v, 0.1) of at least 100 microns and a D(v, 0.5) of between 300 and 800 microns;
pores of said porous carrier are impregnated with an amount of active compound that has solidified therein; and
the active compound is selected from:
lactylate in accordance with formula 1 ,
R2-COO—[—CH(CH 3 )—COO] n —R1  Formula 1

or a Na, K, Ca, Mg, Fe(II), Zn, NH, or Cu(II) salt thereof,
a glycolylate of formula 2,
R2-COO—[—CH 2 —COO] n —R1  Formula 2

or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof,
a lactate ester of formula 3,
HO—CH(CH 3 )—COO—R2  Formula 3

and/or
a glycolic acid ester of formula 4,
HO—CH 2 —COO—R2  Formula 4

wherein in the above formulae:
R1 is selected from H,
n stands for an integer with a value of 1-10, and
R2 stands for a C1-C35 alkyl or alkenyl chain which may be branched or unbranched.

2. The powder according to claim 1 , which comprises at least 20 wt. % of the active compound.

3. The powder according to claim 1 , wherein the carrier has a surface area, as determined through BET, of at least 10 m 2 /g.

4. The powder according to claim 1 , wherein the carrier has a pore volume of from 0.1 to 1.5 ml/g.

5. The powder according to claim 1 , wherein the carrier has a bulk density of at least 0.1 g/ml.

6. The powder according to claim 1 , wherein the carrier is a porous inorganic oxide.

7. The powder according to claim 6 , wherein the carrier is a powder comprising one or more of alumina, silica, titania, diatomaceous earth, and clays.

8. The powder according to claim 7 , wherein the clays are selected from smectite clays and anionic clays.

9. The powder according to claim 7 , wherein the carrier is a powder comprising diatomaceous earth, sepiolite, or vermiculite.

10. The powder according to claim 1 , wherein the carrier is an organic porous material.

11. The powder according to claim 1 , wherein the active compound is a lactylate of formula 1 or a salt thereof.

12. The powder according to claim 11 , wherein the active compound is selected from lauroyl lactylate, myristolyl lactylate, and their sodium salts.

13. A method for manufacturing the powder according to claim 1 , comprising a step of contacting the active compound in liquid form with the carrier.

14. The method according to claim 13 , wherein the step of contacting the active compound in liquid form with the carrier is carried out under reduced pressure.

15. An animal nutrition composition comprising the powder according to claim 1 and at least one further nutritious component.

16. A method for increasing growth of an animal, comprising feeding the animal an effective amount of the powder of claim 1 .

17. The powder according to claim 1 , wherein the carrier has a pore volume of from 0.4 to 1.5 ml/g.

Assignees

• Kok Symone
• Vogiatzis Nikolaos
• Purac Biochem Bv

Inventors

• Kok Symone
• Vogiatzis Nikolaos

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A23K40/10

  by agglomeration; by granulation, e.g. making powders · CPC title