Fluid property measurement devices, methods, and systems

Patent metadata

Field	Value
Publication number	US-9846085-B2
Application number	US-201314416606-A
Country	US
Kind code	B2
Filing date	Jul 25, 2013
Priority date	Jul 25, 2012
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

High accuracy temperature measurement devices, methods, and systems for measuring the temperature of medical fluids are described. In embodiments, the devices have the features that they are compatible with the measurement of temperatures in a sealed fluid circuit, thereby promoting compatibility with sterile disposable circuits. Also described are combinations of temperature sensors and conductivity measurement for precise determination of the concentration of ions in a medicament.

First claim

What is claimed is:

1. A vessel/channel with a temperature detecting device, comprising:
a first temperature sensor attached to or placed against a wall of a vessel/channel configured for carrying or containing a fluid;
a second temperature sensor separated from the first temperature sensor along an axis by an insulating body having a thermal resistance similar to the vessel/channel wall; and
a temperature regulating device in thermal contact with the second temperature sensor and configured to receive first and second temperature indication signals, respectively, from the first and second temperature sensors, wherein
the temperature regulating device is further configured to minimize a difference in temperatures indicated by said first and second temperature signals by regulating a rate of flow of heat between the first and second temperature sensors,
the first temperature sensor has at least one substantially planar face normal to said axis;
the temperature regulating device has a surface substantially parallel to the planar face of the first temperature sensor and extending beyond the planar face.

2. The device of claim 1 , wherein the temperature regulating device includes a thermoelectric heat pump or a dissipative heater.

3. The device of claim 1 , wherein the insulating body fills an empty space between the second temperature sensor and the fluid vessel/channel wall.

4. The device of claim 1 , wherein the vessel/channel is a bag or flexible membrane configured to contain a medicament or a biological fluid.

5. A temperature detecting device, comprising:
a first temperature sensor attached to a flat member that is adapted to be placed against a wall of a vessel/channel configured for carrying or containing a fluid;
a second temperature sensor separated from the first temperature sensor by an insulating air gap;
a temperature regulating device in thermal contact with the second temperature sensor, and
a controller configured to receive first and second temperature indication signals, respectively, from the first and second temperature sensors and to regulate said temperature regulating device responsively to the temperature indication signals therefrom;
the controller being configured to regulate a heat flux rate through said flat member responsively to said temperature indication signals from said first and second temperature sensors such that a temperature of at least said first temperature sensor indicates a temperature of a fluid on a side of said wall opposite said first temperature sensor.

6. The device of claim 5 , wherein the temperature regulating device includes a thermoelectric heat pump.

7. The device of claim 5 , wherein the temperature regulating device includes a dissipative heater.

8. The device of claim 5 , wherein at least one of the second temperature sensor and or the temperature regulating device has a surface that extends beyond a surface of the first temperature sensor.

9. The device of claim 5 , wherein the vessel/channel is a bag or flexible membrane configured to contain a medicament or a biological fluid, or the vessel/channel is a fluid circuit configured to convey a medicament or a biological fluid.

10. The device according to claim 5 , wherein
the flat member includes a substantially circular portion and an elongate portion.

11. A temperature detecting device, comprising:
a first temperature sensor attached to a first flat member that includes a first flexible circuit substrate and is adapted to be placed against a wall of a vessel/channel configured for carrying or containing a fluid;
a second temperature sensor attached to a second flat member that includes a second flexible circuit substrate, separated from the first temperature sensor by a spacer having a toroidal shape;
a temperature regulating device in thermal contact with the second flat member opposite the second temperature sensor, and
a controller configured to receive first and second temperature indication signals, respectively, from the first and second temperature sensors and to regulate said temperature regulating device responsively to the temperature indication signals therefrom;
the controller being configured to regulate a heat flux rate through said first flat member or said second flat member responsively to said temperature indication signals from said first and second temperature sensors such that a temperature of at least said first temperature sensor indicates a temperature of a fluid on a side of said wall opposite said first temperature sensor.

12. The device of claim 11 , wherein the temperature regulating device includes a thermoelectric heat pump or a dissipative heater.

13. The device of claim 11 , wherein the spacer and first and second flat members are adhesively or thermally bonded together.

14. The device of claim 11 , further comprising a heat transfer member of Aluminum Nitride or Beryllium Oxide, the heat transfer member being disposed adjacent said second temperature sensor and adapted for maintaining a uniform temperature across the temperature regulating device.

15. The device of claim 11 , wherein the first and second flat members carry conductors that make electrical contact between the temperature sensors and the controller.

16. The device of claim 15 , wherein the first and second flat members have electrical leads arranged in a manner such that each electrical lead follows an indirect path from an end portion of one of the first and second flat members, whereby thermal conduction from the first and second temperature sensors in a radial direction is minimized.

17. The device of claim 16 , wherein the indirect paths are such that the electrical leads circumscribe, at least partly, the first and second temperature sensors.

18. The device of claim 16 , wherein the indirect paths are such that the electrical leads are serpentine.

19. The device of claim 16 , wherein the indirect paths are such that the electrical leads curve around the first and second temperature sensors.

20. The device of claim 16 , wherein each said end portion is substantially round and major portions of the electrical leads follow a respective path that is substantially tangential to a circumference of one of the end portions.

21. The device of claim 20 , wherein the indirect paths are such that the major portions of the electrical leads double back on themselves.

22. The device of claim 11 , further comprising a heat transfer member of metal or ceramic adjacent said second temperature sensor and adapted for maintaining a uniform temperature across the temperature regulating device.

23. The device of claim 11 , further comprising:
a thermally conductive attachment portion on one, both of, or between the spacer and the first and second flat members, adapted to distribute heat in directions forming a right angle to the line between the first and second temperature sensors, wherein
the thermally conductive attachment portion is thicker than the first or second flat member.

24. The device according to claim 23 , wherein
the thermally conductive attachment portion has a cup shape with a recess that accommodates the first flat member, the spacer, and the second flat member.

25. The device according to claim 24 , wherein
the thermally conductive attachment portion is made of a metal.

26. The device according to claim 25 , wherein
the metal is one of aluminum, copper, and gold.

Assignees

• Nxstage Medical Inc

Inventors

• Newell Scott W
• Kogan Yakov

Classifications

• G01K2013/026

  Physics · mapped topic

• G01K7/16

  using resistive elements · CPC title

• G01K1/14 Primary

  Supports; Fastening devices; Arrangements for mounting thermometers in particular locations · CPC title

• G01K13/026

  of moving liquids · CPC title