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Vibro-based delivery system and immune suppression
US9845341B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9845341-B2 |
| Application number | US-201414770919-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2014 |
| Priority date | Mar 11, 2013 |
| Publication date | Dec 19, 2017 |
| Grant date | Dec 19, 2017 |
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- Title
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Abstract
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Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus ; and drug delivery vehicles derived from a V. parahaemolyticus expressing a mutant VopZ protein lacking amino acid residue 38-62.
First claim
Opening claim text (preview).
What is claimed: 1. A method comprising administering to a host subject a composition comprising an isolated live attenuated bacterium comprising a nucleic acid encoding a mutant VopZ protein that lacks at least the amino acid residues 38-62 of SEQ. ID. NO:1, wherein the attenuated bacterium does not cause diarrhea normally associated with Vibro parahaemolyticus in the host subject.
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Inventors
Classifications
- C07K14/28Primary
from Vibrionaceae (F) · CPC title
containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP] · CPC title
containing a tag with affinity for a non-protein ligand · CPC title
Bacteria (therapeutic use of a bacterial protein A61K38/00) · CPC title
Bacterial antigens · CPC title
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- What does patent US9845341B2 cover?
- Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus ; and drug delivery vehicles derived from a V. parahaemolyticus expressing a mutant VopZ protein lacking amino acid residue 38-62.
- Who is the assignee on this patent?
- Brigham & Womens Hospital Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K14/28. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 19 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).