Cycloalkane derivatives

Patent metadata

Field	Value
Publication number	US-9845313-B2
Application number	US-201615269485-A
Country	US
Kind code	B2
Filing date	Sep 19, 2016
Priority date	Feb 9, 2012
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

Disclosed herein are therapeutic agents and/or preventive agents for pain or therapeutic agents and/or preventive agents for a sodium channel associated disease. The present invention provides compounds represented by the following formula (I) or pharmacologically acceptable salts thereof:

First claim

What is claimed is:

1. A crystalline form of 4-{[(1R,2S)-2-(1-Ethyl-1H-pyrazol-5-yl)cyclopentyl]oxy}-2,3-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide comprising the following peaks in the x-ray powder diffraction pattern:

Peak No.
2θ

1
7.3

2
14.6

3
15.3

4
16.6

5
19.4

6
21.4

7
22.1

8
23.4

9
23.8

10
29.5

11
30.6

.

2. A crystalline form of 4-{[(1S,2R)-2-(1-Ethyl-1H-pyrazol-5-yl)cyclopentyl]oxy}-2,3-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide comprising the following peaks in the x-ray powder diffraction pattern:

Peak No.
2θ

1
7.3

2
14.6

3
15.3

4
16.6

5
19.4

6
21.4

7
22.0

8
23.4

9
23.8

10
29.5

11
30.6

.

3. A crystalline form of 5-Chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide comprising the following peaks in the x-ray powder diffraction pattern:

Peak No.
2θ

1
10.0

2
14.2

3
18.0

4
19.6

5
20.1

6
20.8

7
21.2

8
21.5

9
24.3

10
25.6

11
27.1

.

4. A crystalline form of 5-Chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide comprising the following peaks in the x-ray powder diffraction pattern:

Peak No.
2θ

1
9.0

2
14.8

3
15.2

4
17.8

5
19.3

6
20.0

7
20.5

8
22.3

9
23.3

Assignees

• Daiichi Sankyo Co Ltd

Inventors

• Shinozuka Tsuyoshi
• Kobayashi Hiroyuki
• Suzuki Sayaka
• Tanaka Kyosuke
• Kimoto Hiroko
• Domon Yuki

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/06

  Antimigraine agents · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title