Stimulation of the forno-dorso-commissure (FDC) for seizure suppression and memory improvement

Patent metadata

Field	Value
Publication number	US-9844673-B2
Application number	US-201615281548-A
Country	US
Kind code	B2
Filing date	Sep 30, 2016
Priority date	Jan 17, 2013
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

Example apparatus and methods cause activation of target neural tissue through electrical stimulation of a connected white matter tract to reduce the hyper-excitability of the target neural tissue and thus reduce seizures while preserving memory in humans. Example apparatus and methods apply low frequency (e.g., <10 HZ) electrical stimulation to the forno-dorso-commissure (FDC), detect an electrical signal generated in an area connected to, innervated by, or that can be activated by the FDC in response to the stimulation, and reconfigure the stimulation based on the detected signal and a desired therapeutic effect. The stimulation may be reconfigured to produce an electrical stimulation waveform that will produce the desired therapeutic effect. The desired therapeutic effect may be, for example, reducing hyper-excitability of neural tissue in a target area, reducing hippocampal spikes, reducing seizure odds, or improving recall.

First claim

Having described the invention what is claimed is:

1. A method comprising:
applying an electrical stimulation signal with a frequency of less than 10 Hz to a white matter tract in the brain for a time; and
reducing hyper-excitability of a target neural tissue that is activated by the white matter tract,
wherein the hyper-excitability is reduced as a carryover therapeutic effect for at least four hours after the time.

2. The method of claim 1 , wherein the white matter tract comprises the forno-dorso-commissure (FDC).

3. The method of claim 1 , wherein the electrical stimulation signal is applied according to one or more configurable properties by an implanted stimulating electrode.

4. The method of claim 3 , further comprising updating the one or more configurable properties to reduce the hyper-excitability of the target neural tissue.

5. The method of claim 3 , wherein the one or more configurable properties comprise at least one of a type of waveform, a pulse width, a current intensity, a current amplitude, and a voltage amplitude.

6. The method of claim 5 , wherein the updating is based on a feedback signal that indicates the hyper-excitability of the target neural tissue.

7. The method of claim 6 , wherein the feedback signal indicates an impedance of the target neural tissue,
wherein the impedance correlates to the hyper-excitability of the target neural tissue.

8. The method of claim 1 , wherein the target neural tissue comprises at least a portion of the hippocampus, the posterior cingulate gyrus, or the amygdala.

9. The method of claim 1 , wherein the hyper excitability is indicative of seizure behavior.

10. The method of claim 1 , wherein a duty cycle associated with the electrical stimulation signal is low such that a small amount of electric current is injected into the target tissue.

11. A system comprising:
a stimulation generator to generate an electrical stimulation signal with a frequency of less than 10 Hz; and
at least one electrode to apply the electrical stimulation signal to a white matter tract in the brain for a time; and
wherein hyper-excitability of a target neural tissue that is activated by the white matter tract is reduced as a carryover therapeutic effect for at least four hours after the time.

12. The system of claim 11 , wherein the white matter tract comprises the forno-dorso-commissure (FDC).

13. The system of claim 11 , wherein the stimulation generator alters the electrical waveform in response to a change of one or more configurable parameters in response to a feedback signal that indicates the hyper excitability of the target neural tissue,
wherein the change of the one or more configurable parameters reduces the hyper-excitability of the target neural tissue.

14. The system of claim 13 , wherein the one or more configurable parameters comprise at least one of a type of waveform, a pulse width, a current intensity, a current amplitude, and a voltage amplitude.

15. The system of claim 13 , wherein the feedback signal indicates an impedance of the target neural tissue,
wherein the impedance correlates to the hyper-excitability of the target neural tissue.

16. The system of claim 11 , wherein the target neural tissue comprises at least a portion of the hippocampus, the posterior cingulate gyrus, or the amygdala.

17. The system of claim 11 , wherein the hyper excitability is indicative of seizure behavior.

18. The system of claim 11 , wherein the stimulation generator further comprises a feedback circuit to receive a feedback signal from at least one recording electrode.

19. The system of claim 18 , wherein the at least one recording electrode comprises an implanted electrode or an external electrode.

20. The system of claim 11 , wherein the electrical stimulation signal has a frequency of less than 5 Hz.

Assignees

• Univ Case Western Reserve

Inventors

• Koubeissi Mohamad
• Durand Dominique
• Miller Jonathan
• Luders Hans

Classifications

• A61N1/36139

  with automatic adjustment · CPC title

• A61N1/36082

  Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease · CPC title

• A61N1/36064 Primary

  Epilepsy · CPC title

• A61N1/36092

  Mental training · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title