Accelerated healing of eye injuries by angiotensin peptides

Patent metadata

Field	Value
Publication number	US-9844578-B2
Application number	US-201414784251-A
Country	US
Kind code	B2
Filing date	Apr 30, 2014
Priority date	Apr 30, 2013
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

Disclosed herein are methods for treating eye injuries by administering one or more angiotensin peptides to a subject with an eye injury.

First claim

We claim:

1. A method for treating an eye injury, comprising administering to a subject with an eye injury an amount effective of a peptide comprising Nle3-A(1-7) (SEQ ID NO: 14) to treat the eye injury.

2. The method of claim 1 , wherein the eye injury is caused by trauma, light/radiation or chemical exposure, disease, or a surgical procedure.

3. The method of claim 1 , wherein the eye injury comprises an injury selected from the group consisting of post-surgical inflammation, postoperative fibrosis, a post-surgical increase in intra-ocular pressure, a corneal injury, a cataract incision, laser-assisted in situ keratomileusis (LASIK) wounds, dry eye, and a photorefractive keratectomy (PRK) wound.

4. The method of claim 1 , wherein the eye injury is a corneal injury, and wherein the corneal injury comprises penetration of the corneal epithelium, corneal endothelium, corneal Bowman's membrane, Descemet's membrane and/or anterior part of the corneal stroma, or wherein the corneal injury comprises a corneal abrasion or corneal laceration.

5. The method of claim 4 wherein the treating comprises one or more of (a) reduced time to corneal healing and/or anterior chamber formation compared to control, and (b) reducing development and/or severity of a symptom selected from the group consisting of fibrosis, inflammation, edema, increases in intraocular pressure, eye pain, increased tearing compared to normal, blurred vision, sensitivity to light, altered visual acuity, and a sensation of something being stuck in the eye.

6. The method of claim 1 wherein the eye injury comprises dry eye.

7. The method of claim 4 , wherein the treating comprises reducing development and/or severity of a symptom selected from the group consisting of eye irritation, stinging, redness, grittiness, scratchiness, burning, conjunctival discharge, a feeling of something in the eyes, excess watering, and blurred vision.

8. The method of claim 1 wherein the eye injury results from ocular surgery.

9. The method of claim 8 , wherein the ocular surgery is selected from the group consisting of keratomilleusis, laser-assisted in situ keratomilleusis (LASIK), automated lamellar keratoplasty (ALK), laser assisted sub-epithelial keratomileusis (LASEK), photorefractive keratectomy (PRK), laser thermal keratoplasty (LTK), conductive keratoplasty (CK), limbal relaxing incisions (LRI), astigmatic keratotomy (AK), radial keratotomy (RK), mini-asymmetric radial keratotomy (M.A.R.K.), hexagonal keratotomy (HK), implantable contact lenses, presbyopia reversal, anterior ciliary sclerotomy (ACS), laser reversal of presbyopia (LRP), scleral expansion bands, the Karmra inlay, scleral reinforcement surgery, corneal transplant surgery, penetrating keratoplasty (PK), keratoprosthesis implantation (KPro), cataract surgery, insertion of intra-ocular lenses, phototherapeutic keratectomy (PTK), pterygium excision, corneal tattooing, vitrectomy, pan retinal photocoagulation (PRP), retinal detachment repair, laser photocoagulation, pneumatic retinopexy, retinal cryopexy, macular hole repair, partial lamellar sclerouvectomy, partial lamellar sclerocyclochoroidectomy, partial lamellar sclerochoroidectomy, posterior sclerotomy, radial optic neurotomy, macular translocation surgery, eye muscle surgery, oculoplastic surgery, and surgery to treat cataracts, glaucoma, and diabetic retinopathy.

10. The method of claim 1 , wherein the treating comprises reducing development and/or severity of a symptom selected from the group consisting of postoperative fibrosis, postoperative inflammation, postoperative increases in intraocular pressure, lacerations, conjunctival discharge, punctures, eye pain, increased tearing compared to normal, blurred vision, sensitivity to light, altered visual acuity, and a sensation of something being stuck in the eye.

11. The method of claim 1 , wherein the peptide consists of Nle3-A(1-7) (SEQ ID NO: 14).

12. The method of claim 1 , wherein the peptide is administered at a concentration of about 0.01% to about 1% on a weight (mg)/volume (ml) basis, or on a weight/weight (mg) basis.

13. The method of claim 1 , wherein the peptide is administered in a topical formulation.

14. The method of claim 13 , wherein the topical formulation is selected from the group consisting of hydrogels, creams, viscoelastics, ointments, pastes, drops, nanoparticles, polymeric-based formulations and lotions.

15. The method of claim 13 , wherein the formulation is administered via a delivery aid selected from the group consisting of a bandage contact lens, contact lens, formix-based implant, eye patch or patched eye, pressure patch, and eye shield.

16. The method of claim 13 , wherein the topical formulation comprises about 0.5% to about 4% hydroxyethyl cellulose (HEC) on a weight (mg)/volume (ml) basis, or on a weight/weight (mg) basis.

17. The method of claim 1 , wherein the method further comprises administering to the subject an amount effective to treat an eye injury of an active agent selected from the group consisting of artificial tears, antibiotics, antivirals, antifungals, analgesics, and anti-inflammatory drugs.

Assignees

• Univ Southern California

Inventors

• Rodgers Kathleen E
• Dizerega Gere S
• Humayun Mark
• Louie Stan
• Abdallah Walid Fouad Ahmed

Classifications

• A61K9/0051

  Ocular inserts or implants · CPC title

• A61K38/085 Primary

  Angiotensins · CPC title

• A61K9/0048

  Eye, e.g. artificial tears · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• A61P27/02

  Ophthalmic agents · CPC title