Pharmaceutical composition and functional food comprising natural extracts for preventing or treating diabetic complications or angiodema

Patent metadata

Field	Value
Publication number	US-9844575-B2
Application number	US-201414759471-A
Country	US
Kind code	B2
Filing date	Jan 10, 2014
Priority date	Jan 10, 2013
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.

First claim

The invention claimed is:

1. A method of preventing or treating diabetic complications or angioedema, comprising administering a pharmaceutical composition to a subject in need thereof, wherein the composition comprises a mixed ethanol extract of Hedera helix leaves and Coptis chinensis as an active ingredient.

2. The method according to claim 1 , wherein the composition is prepared by mixing a Hedera helix leaf ethanol extract and a Coptis chinensis ethanol extract at a ratio of 10:1 to 1:10, or by mixing Hedera helix leaves and a Coptis chinensis at a ratio of 10:1 to 1:10, followed by ethanol extraction.

3. The method according to claim 1 , wherein the composition further comprises an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, billberry, raspberry, or grape seeds.

4. The method according to claim 1 , wherein the composition further comprises metformin.

5. The method according to claim 1 , wherein the ethanol extraction is subject to reflux cooling extraction.

6. The method according to claim 1 , wherein the diabetic complication is diabetic ocular disease, diabetic retinopathy, diabetic cataract, diabetic nephropathy, diabetic neuropathy, diabetic cancer, diabetic heart disease, diabetic osteoporosis, or diabetic arteriosclerosis.

7. The method according to claim 1 , wherein the angioedema is varicose veins, macular edema, or macular degradation.

8. A method for preventing or ameliorating diabetic complications or angioedema, comprising administering a functional food composition to a subject in need thereof, wherein the food composition comprises a mixed ethanol extract of Hedera helix leaves and Coptis chinensis as an active ingredient.

9. The method according to claim 8 , wherein the composition is prepared by mixing a Hedera helix leaf ethanol extract and a Coptis chinensis ethanol extract at a ratio of 10:1 to 1:10, or by mixing Hedera helix leaves and a Coptis chinensis at a ratio of 10:1 to 1:10, followed by ethanol extraction.

10. The method according to claim 8 , wherein the composition further comprises an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen , blueberry, billberry, raspberry, or grape seeds.

11. The method according to claim 8 , wherein the extraction is subject to reflux cooling extraction.

12. The method according to claim 8 , wherein the diabetic complication is diabetic ocular disease, diabetic retinopathy, diabetic cataract, diabetic nephropathy, diabetic neuropathy, diabetic cancer, diabetic heart disease, diabetic osteoporosis, or diabetic arteriosclerosis.

13. The method according to claim 8 , wherein the angioedema is varicose veins, macular edema, or macular degradation.

Assignees

• Korea Inst Oriental Medicine

Inventors

• Kim Jin Sook
• Kim Jung Hyun
• Kim Chan Sik
• Kim Young Sook
• Shon Eun Jin
• Lee Yun Mi
• Jung Dong Ho
• Lee Ik Soo
• Jo Gyu Hyeong
• Kim Joo Hwan

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P7/10

  Antioedematous agents; Diuretics · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title