Infant nutritional product with RRR alpha-tocopherol

Patent metadata

Field	Value
Publication number	US-9844532-B2
Application number	US-201414774889-A
Country	US
Kind code	B2
Filing date	Mar 13, 2014
Priority date	Mar 13, 2013
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

First claim

What is claimed is:

1. A nutritional composition comprising fat, protein, carbohydrates, minerals and from about 5 mg/L to about 100 mg/L of an optimized tocopherol blend having a weight ratio of RRR alpha-tocopherol to RRR gamma-tocopherol of from 4:1 to about 20:1 and less than about 8 mg/L of non-RRR alpha-tocopherol isomer.

2. The nutritional composition of claim 1 , wherein the nutritional composition comprises less than about 5 mg/L of non-RRR alpha-tocopherol isomer.

3. The nutritional composition of claim 1 , wherein the nutritional composition comprises less than about 0.5 mg/L of non-RRR alpha-tocopherol isomer.

4. The nutritional composition of claim 1 , wherein the nutritional composition is substantially free of non-RRR alpha-tocopherol isomer.

5. The nutritional composition of claim 1 , wherein the weight ratio of RRR alpha-tocopherol to RRR gamma-tocopherol ranges from 4:1 to about 15:1.

6. The nutritional composition of claim 1 , wherein the weight ratio of RRR alpha-tocopherol to RRR gamma-tocopherol ranges from 4:1 to about 10:1.

7. The nutritional composition of claim 1 , wherein the weight ratio of RRR alpha-tocopherol to RRR gamma-tocopherol is about 5:1.

8. The nutritional composition of claim 1 , having: (i) from about 20 to about 50 g/L fat; ii) from about 10 to about 15 g/L protein; and iii) at least about 4 mg/L of RRR alpha-tocopherol.

9. The nutritional composition of claim 1 , wherein the nutritional composition comprises a polyunsaturated fatty acid selected from arachidonic acid, docosahexaenoic acid, and a combination thereof.

10. The nutritional composition of claim 1 , wherein the nutritional composition comprises vitamin C.

11. The nutritional composition of claim 1 , wherein the nutritional composition comprises a carotenoid.

12. The nutritional composition of claim 1 , wherein the nutritional composition comprises trans-lutein.

13. The nutritional composition of claim 1 , wherein the nutritional composition is a liquid nutritional product.

14. The nutritional composition of claim 1 , wherein the nutritional composition is a powdered nutritional product.

15. The nutritional composition of claim 1 , wherein the nutritional composition is an infant formula.

16. The nutritional composition of claim 1 , wherein the nutritional composition is a preterm infant formula.

Assignees

• Abbott Lab

Inventors

• Lai Chron-Si
• Kuchan Matthew
• Katz Gary

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A23V2250/712

  Vitamin E · CPC title

• A23V2200/322

  having an effect on the health of the nervous system or on mental function · CPC title

• A61K31/355 Primary

  Tocopherols, e.g. vitamin E · CPC title

• A23L33/15

  Vitamins · CPC title