Electromagnetic system and method

Patent metadata

Field	Value
Publication number	US-9844347-B2
Application number	US-201414257200-A
Country	US
Kind code	B2
Filing date	Apr 21, 2014
Priority date	Feb 13, 2009
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

First claim

What is claimed is:

1. A system for detecting differences in tissue property in a tissue of an animal or human, comprising:
a probe shaped in a configuration so that it may be hand-held comprising a driver coil and a receiver coil;
an alternating current or power supply connected to the driver coil configured to provide a non-sinusoidal, asymmetric signal to the driver coil with a frequency between 1 Hz and 1 MHz for inducing eddy currents in the tissue when the probe is placed adjacent to the tissue;
a measurement circuit, operably connected to the receiver coil and configured to measure a phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil when the driver and receiver coils are positioned adjacent to the tissue, wherein the voltage or current produced in the receiver coil has at least a first and second duty cycle each comprised of multiple peaks and wherein the driver coil and receiver coil has inductances and capacitances so the last peak of the voltage or current produced in the first duty cycle coincides on a sloping side of the first peak of the second duty cycle; and
a hardware processor operably connected to the measurement circuit, the hardware processor programmed with one or more software routines executing on the hardware processor to compare the phase shift between the voltage or current on the driver coil and the voltage or current in the receiver coil to detect differences in tissue property.

2. A system according to claim 1 wherein the measurement circuit is a lock-in amplifier configured to provide a DC output voltage indicative of the detected phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil.

3. A system according to claim 1 , further comprising:
a means for raster scanning the probe at various positions across the tissue; and
wherein the measurement circuit provides the measured phase shift between the input voltage or current imposed on the driver coil and the alternating voltage or current induced in the receiver coil at positions across the tissue in order to create an image.

4. A system according to claim 1 , wherein the measurement circuit is configured to measure a change in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil, and
wherein the hardware processor is programmed with one or more software routines executing on the hardware processor to compare differences in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil to detect the differences in tissue property.

5. A system according to claim 1 , wherein the probe diameter is 13.3 mm.

6. A system according to claim 1 , wherein the alternating current or power supply connected to the driver coil is configured to provide a sawtooth signal to the driver coil; and wherein the system is further comprised of a capacitor added in parallel to the receiver coil.

7. A method for detecting differences in tissue property in a tissue of an animal or human, comprising the steps of:
placing a probe adjacent to the tissue, the probe shaped in a configuration so that it may be hand-held comprising a driver coil and a receiver coil;
connecting an alternating current or power supply to the driver coil;
providing a non-sinusoidal, asymmetric signal to the driver coil with a frequency of between 1 Hz and 1 MHz for inducing eddy currents in the tissue when the probe is placed adjacent to the tissue;
connecting a measurement circuit to the receiver coil;
measuring a phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil when the driver and receiver coils are positioned adjacent to the tissue, wherein the voltage or current produced in the receiver coil has at least a first and second duty cycle each comprised of multiple peaks;
introducing inductances and capacitances in the driver coil and receiver coil so the last peak of the voltage or current produced in the first duty cycle coincides on a sloping side of the first peak of the second duty cycle;
and
processing the measured phase shift data to detect differences in tissue property.

8. A method according to claim 7 , further comprising the steps of: measuring a change in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil, and
comparing differences in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil to detect the differences in tissue property.

9. A system for detecting differences in tissue property identifying in a tissue of an animal or human, comprising:
a probe shaped in a configuration so that it may be hand-held comprising a driver coil and a receiver coil;
an alternating current or power supply connected to the driver coil configured to provide a non-sinusoidal, asymmetric signal to the driver coil with a frequency of between 1 Hz and 1 MHz for inducing eddy currents in the tissue when the probe is placed adjacent to the tissue;
a measurement circuit, operably connected to the receiver coil and configured to measure a phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil when the driver and receiver coils are positioned adjacent to the tissue, wherein the voltage or current produced in the receiver coil has at least a first and second duty cycle each comprised of multiple peaks; and
a hardware processor operably connected to the measurement circuit, the hardware processor programmed with one or more software routines executing on the hardware processor to compare the phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil to detect differences in tissue property; and
a capacitor added in parallel to the receiver coil so the last peak of the voltage or current produced in the first duty cycle coincides on a sloping side of the first peak of the second duty cycle.

10. A system according to claim 9 , wherein the measurement circuit is a lock-in amplifier configured to provide a DC output voltage indicative of the detected phase shift between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil.

11. A system according to claim 9 , further comprising:
a means for raster scanning the probe at various positions across the tissue; and
wherein the measurement circuit is adapted to provide the measured phase shift between the input voltage or current imposed on the driver coil and the alternating voltage or current induced in the receiver coil at positions across the tissue in order to create an image.

12. A system according to claim 9 , wherein the measurement circuit is configured to measure a change in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil, and
wherein the hardware processor is programmed with one or more software routines executing on the hardware processor to compare the differences in amplitude between the voltage or current on the driver coil and the voltage or current produced thereby in the receiver coil to detect the differences in tissue property.

13. A system according to claim 9 , wherein the probe diameter is 13.3 mm.

14. A system according to claim 9 , wherein the capacitor in parallel with the receive

Assignees

• Univ Ohio State

Inventors

• Subramaniam Vishwanath
• West Joseph
• Mcferran Brock Jennifer
• Sequin Emily
• Sun Duxin
• Zou Peng
• Jones Travis Hamilton

Classifications

• A61B5/7282 Primary

  Event detection, e.g. detecting unique waveforms indicative of a medical condition (cough events A61B5/0823; seizures A61B5/4094; sleep apnoea A61B5/4818) · CPC title

• A61B6/566

  involving communication between diagnostic systems · CPC title

• A61B6/4417

  related to combined acquisition of different diagnostic modalities · CPC title

• A61B6/507

  for determination of haemodynamic parameters, e.g. perfusion CT · CPC title

• A61B8/5238

  for combining image data of patient, e.g. merging several images from different acquisition modes into one image · CPC title