Molecularly imprinted polymers selective for nitrosamines and methods of using the same

Patent metadata

Field	Value
Publication number	US-9844230-B2
Application number	US-201414327509-A
Country	US
Kind code	B2
Filing date	Jul 9, 2014
Priority date	May 24, 2004
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

A class of molecularly imprinted polymers that specifically recognizes and binds to nitrosamines members of which class are useful, for example, in analysis and separation of nitrosamines from biological fluids. Such molecularly imprinted polymers are also useful in methods of treating and manufacturing tobacco products and materials.

First claim

The invention claimed is:

1. A molecularly imprinted polymer selective for at least one tobacco-specific nitrosamine, wherein said molecularly imprinted polymer is obtained using a functional or structural analogue of a tobacco-specific nitrosamine as a template, and includes an imprint of the functional or structural analogue of a tobacco-specific nitrosamine.

2. The molecularly imprinted polymer according to claim 1 , wherein said at least one tobacco-specific nitrosamine is derived from nicotine, nornicotine, anabasine or anatabine.

3. The molecularly imprinted polymer according to claim 1 , selective for the nicotine-derived nitrosamine NNAL.

4. The molecularly imprinted polymer according to claim 1 , wherein the polymer has been prepared using an isosteric analogue of a tobacco-specific nitrosamine as a template.

5. The molecularly imprinted polymer according to claim 1 , wherein the polymer has been prepared using 4-(methylpropenyl-amino)-1-pyridin-3-yl-butan-1-ol as a template.

6. The molecularly imprinted polymer according to claim 1 , wherein the polymer has been prepared using pyridine carbinol as a template.

7. The molecularly imprinted polymer according to claim 1 , wherein the polymer has been prepared using a compound that includes a substructure of the tobacco specific nitrosamine.

8. A kit, comprising:
the molecularly imprinted polymer according to claim 1 ; and
instructions for using the molecularly imprinted polymer to perform at least one of detecting, quantifying, and separating nitrosamines in a sample.

9. A smoking article, comprising:
a smoking material; and
the molecularly imprinted polymer according to claim 1 , selective for at least one tobacco-specific nitrosamine found in the thermall decomposition products of the smoking material.

10. The smoking article according to claim 9 , wherein the molecularly imprinted polymer is selective for at least one volatile nitrosamine found in the vapor phase of the thermal decomposition products of the smoking material.

11. A smoke filter, comprising: filter material;
and the molecularly imprinted polymer according to claim 1 .

12. The smoke filter according to claim 11 , wherein the molecularly imprinted polymer is selective for at least one volatile nitrosamine found in the vapor phase of the thermal decomposition products of tobacco or a tobacco substitute.

Assignees

• British American Tobacco Investments Ltd
• British American Tobacco Investments Ltd

Inventors

• Bhattacharyya Sumita
• Mcadam Kevin
• Rees Anthony
• Sellergren Börje
• Widstrand Christine

Classifications

• A24D3/067

  characterised by functional properties · CPC title

• B01J20/268

  Polymers created by use of a template, e.g. molecularly imprinted polymers · CPC title

• A24D3/02

  Manufacture of tobacco smoke filters · CPC title

• G01N33/0098

  Plants or trees (wood G01N33/46) · CPC title

• B01D15/3852

  using imprinted phases or molecular recognition · CPC title