Liquid chromatograph and liquid chromatograph analysis method

Patent metadata

Field	Value
Publication number	US-9841407-B2
Application number	US-201514636403-A
Country	US
Kind code	B2
Filing date	Mar 3, 2015
Priority date	Mar 4, 2014
Publication date	Dec 12, 2017
Grant date	Dec 12, 2017

Abstract

A liquid chromatograph analysis method and a liquid chromatograph minimize analysis time when performing analyses by switching columns and mobile phases. Liquid chromatograph 100 for performing a plurality of analyses according to a schedule table includes: mobile phase switching sections 15, 16 for switching a plurality of mobile phases to select a mobile phase to be used in analysis; column switching sections 31, 33 for switching a plurality of columns 32 a - 32 f to select a column to be used in analysis; and control section 60 including memory 61 for storing an equilibration time of each of the plurality of columns 32 a to 32 f and an equilibration controller 66 for controlling column equilibration. If used columns or used mobile phases are different between two consecutively executed analyses, equilibration controller 66 equilibrates a column used in the later of the two analyses over an equilibration time read out from memory 61.

First claim

The invention claimed is:

1. A liquid chromatograph analysis method in which a sample is analyzed using a liquid chromatograph provided with a function of switching a plurality of columns and a plurality of mobile phases, according to a schedule table in which analysis conditions and execution order of a plurality of analyses are described, the analysis method comprising the steps of:
a) storing an equilibration time of each of the plurality of columns in a memory;
b) reading out, from the memory, an equilibration time of a column used in later one of two analyses consecutively executed in the schedule table, in a case where used columns or used mobile phases are different between the two analyses; and
c) equilibrating the column used in the later analysis over the equilibration time read out from the memory, immediately before the later analysis is performed.

2. The liquid chromatograph analysis method according to claim 1 , further comprising setting the equilibration time of the column used in the later analysis to a default value, in a case where the read-out of the equilibration time of the column used in the later analysis is failed.

3. A liquid chromatograph for analyzing a sample according to a schedule table in which analysis conditions and execution order of a plurality of analyses are described, the liquid chromatograph comprising:
a) a mobile phase switching section for switching a plurality of mobile phases to select a mobile phase to be used in analysis;
b) a column switching section for switching a plurality of columns to select a column to be used in analysis; and
c) a control section including a memory for storing an equilibration time of each of the plurality of columns and an equilibration controller for controlling column equilibration, wherein
in a case where used columns or used mobile phases are different between two analyses consecutively executed in the schedule table, the equilibration controller reads out, from the memory, an equilibration time of a column used in later one of the two analyses, and equilibrates the column used in the later analysis over the equilibration time read out from the memory, immediately before the later analysis is performed.

4. The liquid chromatograph according to claim 3 , wherein, in a case where the read-out of the equilibration time of the column used in the later analysis is failed, the equilibration time of the column used in the later analysis is set to a default value.

Assignees

• Shimadzu Corp

Inventors

• Ohashi Hiroshi

Classifications

• G01N30/8658 Primary

  Optimising operation parameters · CPC title

• G01N30/26 Primary

  Conditioning of the fluid carrier; Flow patterns · CPC title

• G01N30/466

  with separation columns in parallel · CPC title

• G01N2030/342

  fluid composition fixed during analysis · CPC title

• G01N30/468

  involving switching between different column configurations · CPC title