Fluorescent polymers and applications thereof

Patent metadata

Field	Value
Publication number	US-9840583-B2
Application number	US-201414903181-A
Country	US
Kind code	B2
Filing date	Jul 8, 2014
Priority date	Jul 9, 2013
Publication date	Dec 12, 2017
Grant date	Dec 12, 2017

Abstract

In one aspect, block copolymers are described herein. A block copolymer described herein, in some embodiments, comprises a first block comprising a polymer or oligomer formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid; and a second block comprising a polymer or oligomer that differs from the polymer or oligomer of the first block. In some cases, the polycarboxylic acid or polycarboxylic acid equivalent comprises citric acid, a citrate, or an ester of citric acid. The polyol can comprise an α,ω-n-alkane diol, poly(ethylene glycol), or poly(propylene glycol). In some embodiments, the amino acid forms a pendant group of the polymer or oligomer of the first block and/or forms a luminescent 6-membered ring with the polycarboxylic acid or polycarboxylic acid equivalent. The second block of a block copolymer described herein, in some embodiments, comprises a polylactone.

First claim

That which is claimed is:

1. A micelle formed from an amphiphilic polymer, the amphiphilic polymer comprising:
at least one hydrophilic block comprising a hydrophilic polymer or oligomer; and
at least one hydrophobic block comprising a hydrophobic polymer or oligomer,
wherein the hydrophilic polymer or oligomer and/or the hydrophobic polymer or oligomer is formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid, and
wherein the hydrophilic block and the hydrophobic block are bonded together through an ester linkage;
wherein the micelle has a hydrophobic core and a hydrophilic corona; and
wherein a drug is disposed in the hydrophobic core of the micelle.

2. The micelle of claim 1 , wherein the micelle is a fluorescent micelle.

3. A medical device formed at least in part from the micelle of claim 1 .

Assignees

• Univ Texas
• Penn State Res Found

Inventors

• Yang Jian
• Xie Zhiwei

Classifications

• C08G63/6854 Primary

  derived from polycarboxylic acids and polyhydroxy compounds · CPC title

• A61K9/107

  Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• C08G63/914 Primary

  derived from polycarboxylic acids and polyhydroxy compounds · CPC title

• A61K9/1075

  Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence) · CPC title