Fluid mixing system with flexible drive line and foldable impeller

Patent metadata

Field	Value
Publication number	US-9839886-B2
Application number	US-201314390956-A
Country	US
Kind code	B2
Filing date	Mar 14, 2013
Priority date	Apr 6, 2012
Publication date	Dec 12, 2017
Grant date	Dec 12, 2017

Abstract

A fluid mixing system includes a container, such as a flexible bag, bounding a compartment. A flexible drive line is disposed within the compartment, the drive line having a first end rotatably connected to a first end of the container and an opposing second end rotatably connected to a second end of the container. At least one mixing element, such as an impeller, is coupled with the flexible drive line. Rotation of the drive line facilitates rotation of the impeller within the container.

First claim

What is claimed is:

1. A fluid mixing system comprising:
a container bounding a sterile compartment, the container having a first end and an opposing second end;
a flexible drive line disposed within the sterile compartment, the flexible drive line having a length extending between a first end and an opposing second end, the first end of the drive line being rotatably connected to the first end of the container and the opposing second end of the drive line being rotatably connected to the second end of the container, at least 40% of the length of the drive line being sufficiently flexible that it can be twisted under torsion over an angle of at least 180% without plastic deformation; and
at least one mixing element coupled with the flexible drive line.

2. The fluid mixing system as recited in claim 1 , further comprising:
a support housing having a chamber in which the container is at least partially disposed; and
a yoke mounted to the support housing and secured to the second end of the container.

3. The fluid mixing system as recited in claim 1 , wherein the container comprises a flexible bag.

4. The fluid mixing system as recited in claim 1 , wherein the drive line has a longitudinal axis extending along the length thereof, at least 40% of the length of the drive line being sufficiently flexible that it can be bent along the longitudinal axis at an angle of at least 90° without plastic deformation of the drive line.

5. The fluid mixing system as recited in claim 1 , wherein the drive line is comprised of a flexible cable or cord.

6. The fluid mixing system as recited in claim 1 , wherein the drive line is comprised of a flexible tube.

7. The fluid mixing system as recited in claim 1 , wherein the at least one mixing element comprises an impeller coupled with the flexible drive line.

8. The fluid mixing system as recited in claim 7 , wherein the at least one impeller comprises:
a hub; and
a plurality of spaced apart blades hingedly mounted to the hub.

9. The fluid mixing system as recited in claim 1 , further comprising a rigid drive shaft coupled to the first end of the flexible drive line.

10. The fluid mixing system as recited in claim 1 , further comprising:
a first rotational assembly, the first rotational assembly including:
a first casing mounted to the first end of the container; and
a first hub rotatably mounted to the first casing, the first hub being coupled to the first end of the flexible drive line; and

a second rotational assembly, the second rotational assembly including:
a second casing mounted to the second end of the container; and
a second hub rotatably mounted to the second casing, the second hub being coupled to the second end of the flexible drive line.

11. The fluid mixing system as recited in claim 10 , further comprising:
a rigid support housing having a floor and bounding a chamber, the container being at least partially disposed within the chamber so as to rest on the floor; and
a yoke secured to the floor of the support housing and the second casing being removably secured to the yoke.

12. The fluid mixing system as recited in claim 1 , wherein the at least one mixing element is hingedly coupled with the flexible drive line.

13. The fluid mixing system as recited in claim 1 , wherein at least a portion of the drive line has a bend radius wrapped 180° in a range between about 2 cm to about 100 cm without plastic deformation.

14. The fluid mixing system as recited in claim 1 , further comprising means for holding the second end of the container stationary while the flexible drive line is rotated within the compartment of the container.

15. The fluid mixing system as recited in claim 1 , further comprising:
a support housing having a chamber in which the container is at least partially disposed; and
a rotational assembly secured to the second end of the container and rotatably connecting the second end of the drive line to the second end of the container, the rotational assembly being releasably secured to the support housing.

16. The fluid mixing system as recited in claim 10 , further comprising:
a rigid support housing having a floor and bounding a chamber, the container being at least partially disposed within the chamber so as to rest on the floor; and
the second casing being releasably secured to the support housing.

17. The fluid mixing system as recited in claim 1 , wherein the container is comprised of one or more sheets of polymeric film.

18. The fluid mixing system as recited in claim 17 , wherein the polymeric film comprises a multilayer film.

19. The fluid mixing system as recited in claim 1 , wherein at least 80% of the length of the drive line is sufficiently flexible that it can be twisted under torsion over an angle of at least 180% without plastic deformation.

20. A fluid mixing system comprising:
a container bounding a sterile compartment, the container having a first end and an opposing second end;
a flexible drive line disposed within the sterile compartment, the flexible drive line having a length extending between a first end and an opposing second end, the first end of the drive line being rotatably connected to the first end of the container and the opposing second end of the drive line being rotatably connected to the second end of the container;
at least one mixing element coupled with the flexible drive line;
a first rotational assembly, the first rotational assembly including:
a first casing mounted to the first end of the container; and
a first hub rotatably mounted to the first casing, the first hub being coupled to the first end of the flexible drive line;

a second rotational assembly, the second rotational assembly including:
a second casing mounted to the second end of the container; and
a second hub rotatably mounted to the second casing, the second hub being coupled to the second end of the flexible drive line;

a rigid support housing having a floor and bounding a chamber, the container being at least partially disposed within the chamber so as to rest on the floor; and
a yoke secured to the floor of the support housing and the second casing being removably secured to the yoke.

Assignees

• Life Technologies Corp
• Life Tehnologies Corp

Inventors

• Staheli Clinton C
• Knudsen Brandon M
• Williams Trevor G
• Kjar Steven R

Classifications

• C12M23/14

  Bags · CPC title

• C12M23/52

  Mobile; Means for transporting the apparatus (transportable laboratories B01L1/52) · CPC title

• C12M27/02

  Stirrer or mobile mixing elements · CPC title

• B01F7/00291

  Operations & Transport · mapped topic

• B01F15/00707

  Operations & Transport · mapped topic