Compositions and methods relating to proliferative diseases

Patent metadata

Field	Value
Publication number	US-9839618-B2
Application number	US-201615366722-A
Country	US
Kind code	B2
Filing date	Dec 1, 2016
Priority date	Dec 6, 2010
Publication date	Dec 12, 2017
Grant date	Dec 12, 2017

Abstract

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.

First claim

The invention claimed is:

1. An anti-cancer pharmaceutical composition, comprising:
N-tribromoacetylleelamine/GPR-5L N-{[(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methyl}-2,2,2-tribromoacetamide; and a pharmaceutically acceptable carrier.

2. The composition of claim 1 , wherein the pharmaceutically acceptable carrier comprises liposomes.

3. A method of treating a subject having cancer, comprising:
administering a therapeutically effective amount of the anti-cancer pharmaceutical composition of claim 1 to the subject.

4. The method of claim 3 , wherein the anti-cancer pharmaceutical composition is effective to preferentially inhibit the PI3K, MAPK and STAT pathways in a cancer cell compared to a non-cancer cell.

5. The method of claim 3 , wherein the subject is human.

6. The method of claim 3 , further comprising administration of an adjunct anti-cancer treatment.

Assignees

• Penn State Res Found

Inventors

• Robertson Gavin P
• Chandagalu D Raghavendra Gowda
• Madhunapantula Subbarao V
• Inamdar Gajanan S
• Kuzu Omer F

Classifications

• A61K31/136

  having the amino group directly attached to the aromatic ring, e.g. benzeneamine · CPC title

• A61K31/215

  of carboxylic acids · CPC title

• C07C61/29

  having a carboxyl group bound to a condensed ring system · CPC title

• A61K31/135 Primary

  having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)} · CPC title

• A61K31/195

  having an amino group · CPC title