Combating dentine hypersensitivity with a non-ionic polymer

Patent metadata

Field	Value
Publication number	US-9839597-B2
Application number	US-201214008108-A
Country	US
Kind code	B2
Filing date	Mar 28, 2012
Priority date	Mar 30, 2011
Publication date	Dec 12, 2017
Grant date	Dec 12, 2017

Abstract

An oral care composition which is a liquid at or below room temperature and which forms a two-phase cloudy system at body temperature and wherein the composition comprises a water-soluble non-ionic polymer, such as HPC, having a cloud point in the composition at a temperature no higher than about 38° C., for combating (i.e. helping to prevent, inhibit and/or treat) dentinal hypersensitivity.

First claim

The invention claimed is:

1. An oral care composition which is a transparent aqueous solution at or below room temperature and which forms a two-phase cloudy system at body temperature and wherein the composition consists essentially of:
1) hydroxypropyl cellulose having an average molecular weight of about 95,000 to about 370,000 in an amount of from 1 to 5% by weight of the composition and wherein the hydroxypropyl cellulose has a cloud point in the composition at a temperature no higher than about 38° C., and
2) one or more cloud point modifying agents selected from an alkali metal salt in an amount from 0.5 to 5% by weight of the composition or a humectant which is selected from glycerine, sorbitol, propylene glycol or polyethylene glycol or a mixture thereof, in an amount from 2 to 15% by weight of the composition; and
3) water in an amount up to 100% by weight of the composition.

2. A composition according to claim 1 wherein the non-ionic polymer in the composition has a cloud point in the range 32° to 38° C.

3. A composition according to claim 1 wherein the salt comprises sodium citrate.

4. A composition according to claim 1 wherein the humectant is present in an amount ranging from 2 to 10% by weight of the composition.

5. A composition according to claim 1 wherein the humectant comprises glycerine.

6. A composition according to claim 1 wherein the hydroxypropyl cellulose is selected from Klucel GF (M.W.≈370,000), Klucel JF (M.W.≈140,000), Klucel LF (M.W.≈95,000) and Klucel EF (M.W.≈80,000).

7. A composition according to claim 6 wherein the hydroxypropyl cellulose comprises Klucel JF.

8. A composition according to claim 1 wherein the non-ionic polymer is present in an amount ranging from 1 to 5% by weight of the composition.

9. A method of treating dentine hypersensitivity comprising administering a composition according to claim 1 .

Assignees

• Bryske Karin Maria
• Edwards Mark Ieuan
• Gracia Louise
• King Simon
• Lindman Björn Olof
• Glaxo Group Ltd

Inventors

• Bryske Karin Maria
• Edwards Mark Ieuan
• Gracia Louise
• King Simon
• Lindman Björn Olof

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/20

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/731 Primary

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61K2800/5422

  nonionic · CPC title