Integrated nanofluidic arrays for high capacity colloid separation

Patent metadata

Field	Value
Publication number	US-9833782-B2
Application number	US-201615160524-A
Country	US
Kind code	B2
Filing date	May 20, 2016
Priority date	Nov 13, 2015
Publication date	Dec 5, 2017
Grant date	Dec 5, 2017

Abstract

A technique relates to an integrated nanofluidic device. A loading layer includes an inlet channel reservoir, a diverted fraction reservoir, and a passed fraction reservoir. A sorting layer is attached to the loading layer such that fluid is permitted to communicate between the loading and sorting layers, where the sorting layer includes a bank of sorting elements. The sorting layer has inlet channels and outlet channels connected to the sorting elements, and the inlet channel reservoir is connected to the inlet channels by an inlet feed hole. The diverted fraction reservoir is connected to the outlet channels by a diverted fraction outlet feed hole, and the passed fraction reservoir is connected to the sorting elements by passed fraction feed holes. The passed fraction feed holes are respectively connected to the sorting elements.

First claim

What is claimed is:

1. An integrated nanofluidic device comprising:
a loading layer including an inlet channel reservoir, a diverted fraction reservoir, and a passed fraction reservoir; and
a sorting layer attached to the loading layer such that fluid is permitted to communicate between the loading and sorting layers, the sorting layer including a bank of sorting elements, wherein the sorting layer has inlet channels and outlet channels connected to the sorting elements, wherein the inlet channel reservoir is connected to the inlet channels by an inlet feed hole, wherein the diverted fraction reservoir is connected to the outlet channels by a diverted fraction outlet feed hole, and wherein the passed fraction reservoir is connected to the sorting elements by passed fraction feed holes, the passed fraction feed holes respectively connected to the sorting elements, wherein the inlet feed hole and the diverted fraction outlet feed hole are both in the sorting layer.

2. The device of claim 1 , wherein feed-in channels respectively connect to the sorting elements, the feed-in channels each being connected to the inlet channels.

3. The device of claim 1 , wherein diverted fraction outlets respectively connect to the sorting elements, the diverted fraction outlets each being connected to the outlet channels.

4. The device of claim 1 , wherein passed fraction outlets respectively connect to the sorting elements, the passed fraction outlets being connected to the passed fraction feed holes.

5. The device of claim 1 , wherein the inlet channel reservoir has an external via for accessing the inlet channel reservoir.

6. The device of claim 1 , wherein the diverted fraction reservoir has an external via for accessing the diverted fraction reservoir.

7. The device of claim 1 , wherein the passed fraction reservoir has an external via for accessing the passed fraction reservoir.

8. The device of claim 1 , wherein the sorting layer includes other banks of the sorting elements in addition to the bank of the sorting elements.

9. The device of claim 8 , wherein the sorting layer includes rows of the bank and the other banks of the sorting elements.

10. The device of claim 1 , wherein the sorting elements each include a nanopillar array configured to sort particles.

Assignees

• IBM

Inventors

• Smith Joshua T
• Wunsch Benjamin H
• Yang Cornelia T

Classifications

• B01L2300/0896

  Nanoscaled · CPC title

• B01L2400/049

  vacuum · CPC title

• B01L2300/0887

  Laminated structure · CPC title

• B01L2300/0864

  comprising only one inlet and multiple receiving wells, e.g. for separation, splitting · CPC title

• B01L3/502746

  characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves · CPC title