Antiviral compositions

Patent metadata

Field	Value
Publication number	US-9832998-B2
Application number	US-201514663132-A
Country	US
Kind code	B2
Filing date	Mar 19, 2015
Priority date	May 30, 2007
Publication date	Dec 5, 2017
Grant date	Dec 5, 2017

Abstract

The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

First claim

The invention claimed is:

1. A solid antiviral composition comprising
a) a polymeric material that is solid at room temperature and molten at elevated temperatures and, embedded therein;
b) a compound of formula (V):
Y—(CH 2 ) n —X—Z—[X—W—Y] m a B −c   (V)

wherein:
Z represents a modified polyol having more than one primary hydroxyl group in the unmodified state, wherein at least two of the primary hydroxyl groups have been replaced by X—(CH 2 ) n —Y groups;
X represents

n independently represents an integer from 1-100;
W represents —(CH 2 ) n —, —CH 2 (—O—CH 2 —) n —, saturated or unsaturated, substituted or unsubstituted, branched or unbranched alkyl, substituent is a member selected from the group consisting of lower alkoxy, chloro, aryl, phenyl, tolyl, benzyl, styryl and substituted phenyl wherein the substituent is a member selected from the group consisting of nitro, amino and lower alkoxy;
Y represents —NR 2 , — + NR 3 , —PR 2 , — + PR 3 , —OH, —SH, —SR, — + SR 2 , —SO 3 − , —SO 2 —OR, —OR, —C(O)R, —C(O)OR, or a diazabicyclo [2.2.2] octane derivative selected from:

R independently represents H, C n alkyl, or phenyl;
R 1 represents H, C n alkyl, phenyl, —NR 2 , —PR 2 , — + PR 3 , —OH, —SH, —SR, — + SR 2 , —SO 3 − , —OR, —C(O)R, —C(O)OR, or —SO 2 —OR;
m represents any number up to m 1 −1 wherein m 1 represents the number of primary hydroxyl groups in the polyol in the unmodified state;

B represents an anion;
a represents an integer; and
c represents the valence of B, and is equal to 1-3;
wherein a×c represents a number such that the compound is charge balanced.

2. An antiviral surface according to claim 1 , wherein n is an odd number between 1 and 100.

3. An antiviral surface according to claim 1 , wherein n is an even number between 1 and 100.

4. A method for protecting a surface from viral contamination, the method comprising converting the polymeric material to a solid antiviral composition comprising:
a) a polymeric material that is solid at room temperature and molten at elevated temperatures and, embedded therein;
b) a compound of formula (V):
Y—(CH 2 ) n —X—Z—[X—W—Y] m a B −c   (V)

wherein:
Z represents a modified polyol having more than one primary hydroxyl group in the unmodified state, wherein at least two of the primary hydroxyl groups have been replaced by X—(CH 2 ) n —Y groups;
X represents

n independently represents an integer from 1-100;
W represents —(CH 2 ) n —, —CH 2 (—O—CH 2 —) n —, saturated or unsaturated, substituted or unsubstituted, branched or unbranched alkyl, substituent is a member selected from the group consisting of lower alkoxy, chloro, aryl, phenyl, tolyl, benzyl, styryl and substituted phenyl wherein the substituent is a member selected from the group consisting of nitro, amino and lower alkoxy;
Y represents —NR 2 , — + NR 3 , —PR 2 , — + PR 3 , —OH, —SH, —SR, — + SR 2 , —SO 3 − , —SO 2 —OR, —OR, —C(O)R, —C(O)OR, or a diazabicyclo [2.2.2] octane derivative selected from:

R independently represents H, C n alkyl, or phenyl;
R 1 represents H, C n alkyl, phenyl, —NR 2 , —PR 2 , — + PR 3 , —OH, —SH, —SR, — + SR 2 , —SO 3 − , —OR, —C(O)R, —C(O)OR, or —SO 2 —OR;
m represents any number up to m 1 −1 wherein m 1 represents the number of primary hydroxyl groups in the polyol in the unmodified state;

B represents an anion;
a represents an integer; and
c represents the valence of B, and is equal to 1-3;
wherein a×c represents a number such that the compound is charge balanced.

Assignees

• Univ City New York Res Found
• Pace Univ
• Long Island Univ

Inventors

• Engel Robert
• Rizzo Jaimelee Iolani
• Melkonian-Fincher Karin

Classifications

• A61K31/785

  Polymers containing nitrogen · CPC title

• A01N43/90 Primary

  having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system · CPC title

• C08F8/32

  by reaction with amines · CPC title

• C08B15/06

  containing nitrogen {, e.g. carbamates} · CPC title

• D06M2101/12

  Keratin fibres or silk · CPC title