Hydrogel network

Patent metadata

Field	Value
Publication number	US-9831010-B2
Application number	US-201314438345-A
Country	US
Kind code	B2
Filing date	Oct 25, 2013
Priority date	Oct 25, 2012
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices.

First claim

The invention claimed is:

1. A hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises:
(a) a hydrogel body, and
(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body,
wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the hydrogel objects;
wherein said plurality of hydrogel objects comprises a first hydrogel object and a second hydrogel object, wherein each of the first and second hydrogel objects comprises:
(a) a hydrogel body, and
(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body,
wherein the first hydrogel object contacts the second hydrogel object to form an interface between the first and second hydrogel objects; and
the hydrogel body of the first hydrogel object is in direct contact with the hydrogel body of the second hydrogel object, at the interface between the first and second hydrogel objects.

2. A hydrogel network according to claim 1 wherein the interface between the first and second hydrogel objects does not comprise a bilayer of amphipathic molecules.

3. A hydrogel network according to claim 1 wherein said plurality of hydrogel objects further comprises a third hydrogel object, wherein the third hydrogel object comprises:
(a) a hydrogel body, and
(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body,
wherein the first or second hydrogel object contacts the third hydrogel object to form an interface between the first or second hydrogel object and the third hydrogel object.

4. A hydrogel network according to claim 3 wherein the first hydrogel object contacts the third hydrogel object to form an interface between the first and third hydrogel objects, and wherein the second hydrogel object contacts the third hydrogel object to form an interface between the second and third hydrogel objects.

5. A hydrogel network according to claim 1 wherein the network comprises at least n of said hydrogel objects, and at least n−1 of said interfaces between hydrogel objects, wherein n is equal to or greater than 2.

6. A hydrogel network according to claim 3 , wherein at least one of the interfaces between hydrogel objects comprises a bilayer of amphipathic molecules.

7. A hydrogel network according to claim 3 wherein at least one of the interfaces between hydrogel objects comprises a bilayer of amphipathic molecules, and at least one other of the interfaces between hydrogel objects does not comprise a bilayer of amphipathic molecules.

8. A hydrogel network according to claim 3 wherein at least one of the interfaces between hydrogel objects comprises a bilayer of amphipathic molecules, and wherein the hydrogel body of one hydrogel object is in direct contact with the hydrogel body of another hydrogel object at at least one other of the interfaces between hydrogel objects.

9. A hydrogel network according to claim 1 wherein the hydrogel body of at least one of said hydrogel objects is a molded three-dimensional hydrogel shape.

10. A hydrogel network according to claim 9 wherein the three-dimensional shape is spherical, cross-shaped, cuboid, crescent-shaped, prism-shaped, cylindrical, wire-shaped or a shape which has a triangular, pentagonal, hexagonal, heptagonal, octagonal, nonagonal, decagonal, undecagonal, dodecagonal, square or rectangular face.

11. A hydrogel network according to claim 1 wherein the hydrogel body of at least one of said hydrogel objects is in the shape of a wire.

12. A hydrogel network according to claim 8 wherein at least one of said bilayers further comprises a membrane protein, wherein the membrane protein is a pump, channel or a pore, a receptor protein, a transporter protein, or a protein which effects cell recognition or a cell-to-cell interaction.

13. A hydrogel network according to claim 1 wherein the hydrogel body comprises a hydrogel comprising agarose.

14. A hydrogel network according to claim 1 , wherein the amphipathic molecules comprise lipid molecules.

15. A hydrogel network according to claim 1 which further comprises a hydrophobic medium, wherein the plurality of hydrogel objects is disposed in the hydrophobic medium.

16. A hydrogel network comprising a plurality of hydrogel objects,
wherein each of said hydrogel objects comprises:
(a) a hydrogel body, and
(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body,

wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the hydrogel objects;
wherein at least one of said plurality of hydrogel objects is a Janus particle comprising:
(a) a hydrogel body comprising a hydrophilic material and a hydrophobic material, and
(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body.

17. A hydrogel network according to claim 16 , wherein the hydrophilic material is on one side of the hydrogel body and the hydrophobic material is on the other side of the hydrogel body.

Assignees

• Isis Innovation
• Univ Oxford Innovation Ltd

Inventors

• Bayley John Hagan Pryce
• Sapra Kunwar Tanuj

Classifications

• G01N33/6872

  Intracellular protein regulatory factors and their receptors, e.g. including ion channels · CPC title

• G01N27/416

  Systems (G01N27/27 takes precedence) · CPC title

• B32B17/06

  comprising glass as the main or only constituent of a layer, next to another layer of a specific {material} · CPC title

• C12M1/3407

  Measure of electrical or magnetical factor · CPC title

• C12M1/34

  Measuring or testing with condition measuring or sensing means, e.g. colony counters · CPC title