Biocompatible tubing for liquid chromatography systems

Patent metadata

Field	Value
Publication number	US-9829123-B2
Application number	US-201514703717-A
Country	US
Kind code	B2
Filing date	May 4, 2015
Priority date	Jul 16, 2010
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

A biocompatible tube and fitting system that can be used in a liquid chromatography system is described. The tube can have a polymer tip and can be used in conjunction with one or more fitting assembly.

First claim

We claim:

1. A tube and fitting system for use in a liquid chromatography system, comprising: a) a tube comprising: i) an outer layer having an inner surface and an outer surface, and having a first and a second end, wherein at least one of the first and second ends of said outer layer comprises a tip portion, wherein the tip portion comprises a polymer; and ii) a biocompatible inner layer having a passageway therethrough and having a first and a second end, wherein said inner layer is located within said outer layer; and b) a fitting comprising a first ferrule and a second ferrule, wherein the first ferrule comprises a metal and the second ferrule comprises a polymer, wherein the first ferrule is adapted to hold the tube by the outer layer and the second ferrule is adapted to seal the tube on the tip portion.

2. The tube and fitting system according to claim 1 wherein said outer layer comprises a metal.

3. The tube and fitting system according to claim 2 wherein said outer layer comprises one or more metals selected from the group comprising: stainless steel, or titanium.

4. The tube and fitting system according to claim 1 , wherein said biocompatible inner layer comprises polyetheretherketone (PEEK).

5. The tube and fitting system according to claim 1 , wherein said tip portion comprises PEEK.

6. The tube and fitting system according to claim 1 , further comprising at least a first fitting assembly, wherein said fitting assembly comprises: a nut having a first end and a second end, and having, a passageway therethrough, wherein said passageway has an internally tapered portion and a lip proximal said second end of said nut, and wherein said second end of said nut has an externally threaded portion, wherein said first ferrule is adapted to securely engage with said tapered portion of said passageway in said nut, wherein said second ferrule has a first externally tapered end, a central portion, and a second externally tapered end, wherein said first externally tapered end and said central portion define a first lip and said second externally tapered end and said central portion define a second lip, and wherein said first end of said second ferrule is adapted to abut with said second end of said first ferrule within said passageway of said nut, and said first lip of said second ferrule securely engages said lip of said nut.

7. The tube and fitting system according to claim 1 wherein said biocompatible inner layer comprises one or more polymers selected from the group consisting of: polyetheretherketone (PEEK), DELRIN, perfluoroalkoxy (PFA, also called perfluoroalkoxyethylene), fluorinated ethylene propylene (PEP), polytetrafluoroethylene (PTFE), ETFE (a polymer of tetrafluoroethylene and ethylene), polyetherimide (PEI), polyphenylene sulfide (PPS), polypropylene, sulfone polymers, polyolefins, polyimides, polyaryletherketones, fluoropolymers, or polyoxymethylene (POM).

8. The tube and fitting system according to claim 1 wherein said outer layer comprises a polymer.

9. The tube and fitting system according to claim 8 wherein said outer layer comprises one or more polymers selected from the group consisting of: polymers reinforced with carbon, carbon fibers, or steel fibers, or polymers braided with carbon, carbon fibers, or steel fibers, or a combination thereof.

10. The tube and fitting system according to claim 1 wherein the outer surface of said biocompatible inner layer comprises a coating material.

11. The tube and fitting system according to claim 10 wherein said coating comprises one or more of the following: a metallization coating, a polymeric coating, a silicon-based coating, and a carbon-based coating.

12. The tube and fitting system according to claim 1 wherein said tip portion comprises one or more polymers selected from the group consisting of: polyetheretherketone (PEEK), DELRIN, perfluoroalkoxy (PFA, also called perfluoroalkoxyethylene), fluorinated ethylene propylene (PEP), polytetrafluoroethylene (PTFE), ETFE (a polymer of tetrafluoroethylene and ethylene), polyetherimide (PEI), polyphenylene sulfide (PPS), polypropylene, sulfone polymers, polyolefins, polyimides, polyaryletherketones, fluoropolymers, or polyoxymethylene (POM).

Assignees

• Idex Health & Science Llc

Inventors

• Hahn Mark
• Ellis Scott J
• Beemer Eric

Classifications

• G01N30/6073

  in open tubular form · CPC title

• G01N30/6026

  Fluid seals · CPC title

• F16L9/14

  Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups (F16L9/16 - F16L9/22 take precedence) · CPC title

• F16L58/10

  by rubber or plastics · CPC title

• G01N30/6004 Primary

  end pieces · CPC title