L-malate production by metabolically engineered escherichia coli
US-9187772-B2 · Nov 17, 2015 · US
Genes and processes for the production of clavine-type alkaloids
US9828617B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9828617-B2 |
| Application number | US-201314421872-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 13, 2013 |
| Priority date | Aug 22, 2012 |
| Publication date | Nov 28, 2017 |
| Grant date | Nov 28, 2017 |
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Abstract
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Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
First claim
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The invention claimed is: 1. A recombinant microorganism comprising an exogenous or overexpressed polynucleotide encoding a polypeptide that is capable of converting chanoclavine I to cycloclavine when expressed together with polynucleotides having nucleic acid sequences of SEQ ID NOS: 103, 105, and 108, wherein the exogenous or overexpressed polynucleotide encodes a polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 95. 2. The recombinant microorganism of claim 1 which is not a natural ergot alkaloid producer organism and comprises an exogenous polynucleotide encoding a polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 95. 3. The recombinant microorganism of claim 1 , comprising at least one compound selected from the group of compounds consisting of: a. Cycloclavine, b. Festuclavine, c. Agroclavine, d. Chanoclavine aldehyde and e. Chanoclavine I.
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Classifications
- C12N9/001Primary
acting on the CH-CH group of donors (1.3) · CPC title
Oxidoreductases (1.) · CPC title
transferring alkyl or aryl groups other than methyl groups (2.5) · CPC title
Methyltransferases (general) (2.1.1.) · CPC title
Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system (alloxazine or isoalloxazine, e.g. riboflavine C12P25/00) · CPC title
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- What does patent US9828617B2 cover?
- Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
- Who is the assignee on this patent?
- Basf Se, Evolva Sa
- What technology area does this patent fall under?
- Primary CPC classification C12N9/001. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 28 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).