Isolation of non-embryonic stem cells and uses thereof
US-2016237400-A1 · Aug 18, 2016 · US
Isolated human lung progenitor cells and uses thereof
US9828583B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9828583-B2 |
| Application number | US-201314371627-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 11, 2013 |
| Priority date | Jan 13, 2012 |
| Publication date | Nov 28, 2017 |
| Grant date | Nov 28, 2017 |
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Abstract
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Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. Thus, the methods and compositions described herein are advantageous over the present state of knowledge in the art and permit the generation of human lung progenitor cells for treatment, tissue engineering, and screening assays.
First claim
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The invention claimed is: 1. A composition comprising an isolated and viable human Nkx2.1 positive, Sox2 positive proximal airway multipotent progenitor cell and a decellularized adult human lung scaffold, wherein the proximal airway multipotent progenitor cell is committed to the lung lineage. 2. The composition of claim 1 , wherein the cell is Tuj1 negative and Pax8 negative. 3. The composition of claim 1 , wherein the cell is proliferative and differentiates into an airway basal stem cell, a ciliated cell, a Clara cell, a neuroendocrine cell, or a squamous epithelial cell under chosen differentiation conditions. 4. The composition of claim 1 , wherein the scaffold is implantable in a subject. 5. The composition of claim 1 , wherein the scaffold is biodegradable. 6. The composition of claim 1 , wherein the progenitor cell is not isolated from an embryo, an embryonic stem cell or other cell derived in culture from an embryo.
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Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the respiratory system · CPC title
Transforming growth factor beta (TGF-β) · CPC title
Materials at least partially resorbable by the body · CPC title
Stem cells; Progenitors · CPC title
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Frequently asked questions
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- What does patent US9828583B2 cover?
- Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from…
- Who is the assignee on this patent?
- Massachusetts Gen Hospital
- What technology area does this patent fall under?
- Primary CPC classification A61K35/42. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 28 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).