Biomembrane phase-change droplets (pcd), drug carrier and use thereof
US-2016317441-A1 · Nov 3, 2016 · US
Self-assembled pharmaceutical composition for photodynamic therapy
US9827313B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9827313-B2 |
| Application number | US-201514670890-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 27, 2015 |
| Priority date | Sep 26, 2014 |
| Publication date | Nov 28, 2017 |
| Grant date | Nov 28, 2017 |
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Abstract
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The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.
First claim
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What is claimed is: 1. A self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range of 4-7.2, and a ligand B of which surface charge changes at a specific pH range, wherein ligand A is a compound of formula (I): wherein n and m is independently 5-500, and wherein ligand B is a compound of formula (II): wherein n and m is independently 5-500. 2. The self-assembled pharmaceutical composition of claim 1 , wherein said photosensitizer is chlorin E6 (Ce6). 3. The self-assembled pharmaceutical composition of claim 1 , wherein said photosensitizer is bonded to said ligand A and said ligand B. 4. The self-assembled pharmaceutical composition of claim 1 , further comprising an MRI contrasting nanoparticle. 5. The self-assembled pharmaceutical composition of claim 4 , wherein said MRI contrasting nanoparticle is an iron oxide nanoparticle. 6. The self-assembled pharmaceutical composition of claim 5 , wherein the size of said iron oxide nanoparticle is 1 nm-100 nm.
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Classifications
Antineoplastic agents · CPC title
the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA · CPC title
Macromolecular compounds, i.e. oligomers, polymers, dendrimers · CPC title
- A61K31/409Primary
having four such rings, e.g. porphine derivatives, bilirubin, biliverdine (hemin, hematin A61K31/555) · CPC title
- A61K41/0071Primary
PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines · CPC title
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- What does patent US9827313B2 cover?
- The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range …
- Who is the assignee on this patent?
- Snu R&Db Foundation, Inst Basic Science, The Catholic Univ Of Korea Industry-Academic Cooperation Foundation, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/409. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 28 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).