Xanthine oxidase inhibitor and uric acid production inhibitor

Patent metadata

Field	Value
Publication number	US-9827279-B2
Application number	US-200913001814-A
Country	US
Kind code	B2
Filing date	Jul 7, 2009
Priority date	Jul 7, 2008
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

A xanthine oxidase inhibitor and a uric acid-producing inhibitor, each containing an extract from at least one member selected from the group consisting of Zanthoxylum bungeanum, Sorghum nervosum, Cuminum cyminum, Rosa centifolia, Pimenta officinalis, Origanum majorana, Psidium guajava, Pimpinella anisum, Olea europaea, Illicium verum, Canavalia gladiata, Hyssopus officinalis, Ribes nigrum, Vaccinium myrtillus, Artemisia princeps and Haematoxylon campechianum L.

First claim

What is claimed is:

1. A method of controlling or reducing a patient's blood uric acid level in a hyperuricemia patient in need of the same which comprises
orally administering to the hyperuricemia patient a therapeutically effective amount of a Sorghum nervosum extract,
wherein said extract is prepared by a method comprising extracting Sorghum nervosum with an extraction solvent selected from the group consisting of water, ethanol, and a mixture of water and ethanol.

2. The method of claim 1 , wherein the dose of the extract that is administered to the patient is 0.001 to 10 g/kg of body weight per day.

3. The method of claim 1 , wherein the patient's blood uric acid concentration is more than 7 mg/dL.

4. The method of claim 1 , wherein the extraction solvent is water, or a mixture of water and ethanol that contains up to 50% ethanol.

5. The method of claim 1 , wherein the hyperuricemia patient has gout or is in need of reducing the probability of developing gout.

6. The method of claim 5 , wherein the dose of the extract that is administered to the patient is 0.001 to 10 g/kg of body weight per day.

7. The method of claim 5 , wherein the patient's blood uric acid concentration is more than 7 mg/dL.

8. The method of claim 5 , wherein the extraction solvent is water, or a mixture of water and ethanol that contains up to 50% ethanol.

9. The method of claim 5 , wherein the hyperuricemia patient is in need of reducing the probability of developing gout.

Assignees

• Yamamoto Naoki
• Watanabe Isamu
• Suzuki Atsushi
• Hashizume Kohjiro
• Kao Corp

Inventors

• Yamamoto Naoki
• Watanabe Isamu
• Suzuki Atsushi
• Hashizume Kohjiro

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/12

  Antihypertensives · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title