Optical tracking of heart rate using PLL optimization

Patent metadata

Field	Value
Publication number	US-9826940-B1
Application number	US-201514721069-A
Country	US
Kind code	B1
Filing date	May 26, 2015
Priority date	May 26, 2015
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

Systems and methods are provided for determining a pulse rate based on a photoplethysmographic measurement of blood in a portion of subsurface vasculature. A plurality of samples of the photoplethysmographic signal are obtained and a plurality of digital phase-locked loops are operated to generate respective oscillating signals based on the plurality of samples. Respective correlations between the plurality of samples and each of the generated oscillating signals are determined and used to select a subset of the plurality of phase-locked loops. The frequencies of the selected oscillating signals generated by the selected phase-locked loops are determined and used to determine a cardiovascular pulse rate. This method can be performed a plurality of times for a respective plurality of overlapping sets of the obtained plurality of samples to determine pulse rates over time.

First claim

What is claimed is:

1. A method comprising:
receiving a plurality of samples of a signal, wherein the signal is related to a cardiovascular pulse;
generating, based on the plurality of samples, a plurality of oscillating signals using a plurality of digital phase-locked loops, wherein each digital phase-locked loop has a different respective set of operational parameters;
comparing the plurality of samples to each of the generated oscillating signals;
selecting two or more of the generated oscillating signals based on the comparison;
determining a plurality of frequencies based on the selected oscillating signals, wherein each frequency corresponds to a respective one of the selected generated oscillating signals; and
determining a pulse rate based on the determined plurality of frequencies.

2. The method of claim 1 , wherein generating, based on the plurality of samples, the plurality of oscillating signals using the plurality of digital phase-locked loops comprises:
receiving an artifact signal;
filtering the received plurality of samples of the signal based on the artifact signal to generate a plurality of filtered samples; and
generating, based on the plurality of filtered samples, the plurality of oscillating signals using the plurality of digital phase-locked loops.

3. The method of claim 2 , wherein filtering the received plurality of samples of the signal based on the artifact signal comprises applying a least mean squares filter to the received plurality of samples, wherein the artifact signal is an input to the least mean squares filter, and wherein the plurality of filtered samples comprise a difference between the received plurality of samples of the signal and an output of the least mean squares filter.

4. The method of claim 1 wherein receiving a plurality of samples of a signal comprises:
illuminating a portion of subsurface vasculature; and
receiving light emitted from the portion of subsurface vasculature in response to illumination, wherein the plurality of samples of a signal comprise measurements of the received light at a plurality of respective points in time.

5. The method of claim 1 , further comprising:
partitioning the plurality of samples of the signal into a plurality of overlapping subsets of the plurality of samples, wherein the plurality of overlapping subsets of the plurality of samples comprises a first subset of the plurality of samples and a second subset of the plurality of samples, and wherein the first subset of the plurality of samples and the second subset of the plurality of samples overlap; and
wherein generating, based on the plurality of samples, a plurality of oscillating signals using the plurality of digital phase-locked loops comprises: generating, based on the first subset of the plurality of samples, a first plurality of oscillating signals using the plurality of digital phase-locked loops; and generating, based on the second subset of the plurality of samples, a second plurality of oscillating signals using the plurality of digital phase-locked loops;
wherein comparing the plurality of samples and each of the generated oscillating signals comprises: comparing the first set of the plurality of samples to each of the generated oscillating signals in the first plurality of oscillating signals; and comparing the second set of the plurality of samples to each of the generated oscillating signals in the second plurality of oscillating signals;
wherein selecting two or more of the generated oscillating signals based on the comparison comprises: selecting two or more of the first plurality of oscillating signals based on the comparison of the first set of the plurality of samples to each of the selected oscillating signals in the first plurality of oscillating signals; and selecting two or more of the second plurality of oscillating signals based on the comparison of the second set of the plurality of samples to each of the selected oscillating signals in the second plurality of oscillating signals;
wherein determining a plurality of frequencies based on the selected oscillating signals, wherein each frequency corresponds to a respective one of the selected generated oscillating signals comprises: determining a first plurality of frequencies based on the selected first plurality of oscillating signals, wherein each frequency in the first plurality of frequencies corresponds to a respective one of the generated oscillating signals selected from the first plurality of oscillating signals; and determining a second plurality of frequencies based on the selected second plurality of oscillating signals, wherein each frequency in the second plurality of frequencies corresponds to a respective one of the generated oscillating signals selected from the second plurality of oscillating signals; and
wherein determining a pulse rate based on the determined plurality of frequencies comprises: determining a first pulse rate based on the first plurality of frequencies; and determining a second pulse rate based on the second plurality of frequencies.

6. The method of claim 5 , wherein the overlapping subsets of the plurality of samples overlap by approximately 1 second.

7. The method of claim 5 , further comprising:
filtering the determined first and second pulse rates using a bidirectional statistical filter.

8. The method of claim 5 , wherein the operational parameters of each digital phase-locked loop comprise a free-running frequency parameter, wherein a set of one or more digital phase-locked loops operated to generate a respective set of oscillating signals based on a first subset of the plurality of samples have respective free-running frequency parameters selected based on a determined pulse rate corresponding to a second subset of the plurality of samples, and wherein the first subset of samples correspond to a time period that is later in time than a period of time corresponding to the second subset of samples.

9. The method of claim 1 , further comprising:
determining an estimated frequency based on the determined plurality of frequencies;
determining a frequency spectrum of the plurality of samples, wherein the frequency spectrum comprises a plurality of frequency components, each having a respective magnitude; and
determining a frequency of a local maximum of the frequency spectrum, wherein the local maximum is within a specified range of frequencies of the estimated frequency, and wherein determining a pulse rate based on the determined plurality of frequencies comprises determining a pulse rate based on the determined frequency of the local maximum of the frequency spectrum.

10. The method of claim 1 , wherein generating a plurality of oscillating signals using the plurality of digital phase-locked loops comprises operating at least 50 digital phase-locked loops.

11. The method of claim 1 , wherein comparing the plurality of samples to each of the generated oscillating signals comprises determining a respective correlation between the plurality of samples and each of the generated oscillating signals.

12. A system comprising:
a sensor configured to detect a signal, wherein the signal is related to a cardiovascular pulse; and
a controller operably coupled to the sensor, wherein the controller comprises a computing device programmed to perform controller operations comprising:
operating the sensor to obtain a plurality of samples of the signal;
generating, based on the plurality of samples, a plurality of oscillating signals using a plurality of digital phase-locked loops, wherein each digital phase-locked loop has a different respective set of operational parameters;
comparing the plurality of samples to each of t

Assignees

• Verily Life Sciences Llc

Inventors

• Lengerich Christopher Towles

Classifications

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• A61B5/02438

  with portable devices, e.g. worn by the patient · CPC title

• A61B2560/0475

  Special features of memory means, e.g. removable memory cards · CPC title

• A61B5/02416

  using photoplethysmograph signals, e.g. generated by infrared radiation (A61B5/14552 takes precedence) · CPC title

• A61B5/7475

  User input or interface means, e.g. keyboard, pointing device, joystick · CPC title