Antimicrobial compositions comprising esters of hydroxycarboxylic acids

Patent metadata

Field	Value
Publication number	US-9826770-B2
Application number	US-90824406-A
Country	US
Kind code	B2
Filing date	Mar 10, 2006
Priority date	Mar 10, 2005
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, a fatty alcohol ester of a hydroxycarboxylic acid, alkoxylated derivatives thereof, or combinations thereof. The compositions can also include an enhancer component, a surfactant component, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).

First claim

What is claimed is:

1. An antimicrobial composition comprising:
an effective amount of an antimicrobial component comprising a (C7-C14)saturated fatty alcohol ester of a (C2-C8)hydroxycarboxylic acid, a (C8-C22)mono- or poly-unsaturated fatty alcohol ester of a (C2-C8) hydroxycarboxylic acid, an alkoxylated derivative of either of the foregoing, or combinations thereof, wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of hydroxycarboxylic acid; and
the composition further comprises an effective amount of an enhancer component selected from the group consisting of alpha hydroxyacids present in an amount of at least 0.25 wt/wt %, beta hydroxyacids present in an amount of at least 0.1 wt/wt %, a chelating agent present in an amount of at least 0.1 wt/wt %, a (C1-C4)alkyl carboxylic acid present in an amount of at least 0.1 wt/wt %, a (C6-C12)aryl carboxylic acid present in an amount of at least 0.1 wt/wt %, a (C6-C12)aralkyl carboxylic acid present in an amount of at least 0.1 wt/wt %, a (C6-C12)alkaryl carboxylic acid present in an amount of at least 0.1 wt/wt %, or combinations thereof; with the proviso that the composition does not include parabens or phenoxyethanol;
wherein the effective amount of the antimicrobial component in the composition is at least 0.25% by weight;
wherein water is present in less than 10 wt-%, and
wherein the fatty alcohol ester in the antimicrobial component is at least 70% pure.

2. The composition of claim 1 wherein the antimicrobial component comprises (C8-C12) fatty alcohol esters of glycolic acid, lactic acid, 3-hydroxybutanoic acid, or combinations thereof.

3. The composition of claim 1 further comprising a surfactant component.

4. The composition of claim 1 further comprising a hydrophilic component.

5. The composition of claim 1 having at least 3 log reduction in test bacteria in 10 minutes when evaluated by the Antimicrobial Kill Rate Test.

6. The composition of claim 3 , wherein the surfactant component does not comprise an ethoxylated sorbitan fatty acid ester.

7. The composition of claim 1 , wherein the enhancer is a chelating agent present in an amount of at least 1%.

8. The composition of claim 1 , wherein the enhancer is a chelating agent and a ratio of the concentration of the chelating agent to the antimicrobial component in the composition is within a range of 1:1 to 1:10.

9. The composition of claim 1 , wherein the fatty alcohol ester in the antimicrobial component is at least 80% pure.

10. An antimicrobial composition comprising:
an effective amount of an antimicrobial component comprising a (C7-C14)saturated fatty alcohol ester of a (C2-C8)hydroxycarboxylic acid, a (C8-C22)mono- or poly-unsaturated fatty alcohol ester of a (C2-C8) hydroxycarboxylic acid, an alkoxylated derivative of either of the foregoing, or combinations thereof, wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of hydroxycarboxylic acid; and
the composition further comprises an effective amount of an enhancer component selected from the group consisting of alpha hydroxyacids present in an amount of at least 0.25 wt/wt %, beta hydroxyacids present in an amount of at least 0.1 wt/wt %, a chelating agent present in an amount of at least 0.1 wt/wt %, a (C1-C4)alkyl carboxylic acid present in an amount of at least 0.1 wt/wt %, a (C6-C12)aralkyl carboxylic acid present in an amount of at least 0.1 wt/wt %, a (C6-C12)alkaryl carboxylic acid present in an amount of at least 0.1 wt/wt %, or combinations thereof; with the proviso that the composition does not include parabens or phenoxyethanol;
wherein the effective amount of the antimicrobial component in the composition is at least 0.25% by weight;
wherein water is present in less than 10 wt-%, and
wherein the fatty alcohol ester in the antimicrobial component is at least 70% pure.

Assignees

• Scholz Matthew T
• Wang Danli
• 3M Innovative Properties Co

Inventors

• Scholz Matthew T
• Wang Danli

Classifications

• A61P31/10

  Antimycotics · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P31/02

  Local antiseptics · CPC title

• A61L2/18

  Liquid substances · CPC title

• A61L2103/05

  Living organisms or biological materials · CPC title