Chromatograph mass spectrometer and control method therefor

Patent metadata

Field	Value
Publication number	US-9823228-B2
Application number	US-201515312792-A
Country	US
Kind code	B2
Filing date	Jul 29, 2015
Priority date	Jun 12, 2014
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

A technician is forced to determine the measurement time to be used in a selected ion monitoring (SIM) measurement while observing mass spectral data. Thus, mass spectral data and one or a plurality of mass chromatogram data items is generated on the basis of the detection results of an ion detection unit, and, for each corresponding ion component, the measurement time to be used in SIM is determined on the basis of the elution time range represented by each peak waveform of the one or plurality of mass chromatogram data items that have been generated.

First claim

The invention claimed is:

1. A chromatograph mass spectrometer comprising:
a chromatograph unit that separates a sample;
an ion source unit that ionizes components separated by the chromatograph unit;
a mass spectrometry unit that separates the components ionized by the ion source unit depending on masses;
an ion detection unit that detects ion components after mass separation;
a data processing unit that generates mass spectral data and one or a plurality of mass chromatogram data items; and
a control unit that determines measurement time used for selected ion monitoring for each corresponding ion component based on start time and end time of each peak determined by a base line of each peak waveform of the one or a plurality of mass chromatogram data items.

2. The chromatograph mass spectrometer according to claim 1 ,
wherein the control unit sets, as the measurement time, time obtained by adding time with a predetermined width before and/or after a time range corresponding to the base line.

3. The chromatograph mass spectrometer according to claim 1 ,
wherein the control unit determines each peak waveform of the one or a plurality of mass chromatogram data items in parallel with an operation of detecting scanning data by the ion detection unit, and then determines the measurement time for each ion component.

4. The chromatograph mass spectrometer according to claim 1 ,
wherein the chromatograph unit is a liquid chromatograph.

5. The chromatograph mass spectrometer according to claim 1 ,
wherein the chromatograph unit is a gas chromatograph.

6. A method of controlling a chromatograph mass spectrometer including a chromatograph unit that separates a sample, an ion source unit that ionizes components separated by the chromatograph unit, a mass spectrometry unit that separates the components ionized by the ion source unit depending on masses, an ion detection unit that detects ion components after mass separation, a data processing unit that generates mass spectral data and one or a plurality of mass chromatogram data items based on a result of the detection by the ion detection unit, and a control unit that controls operations of the mass spectrometry unit and the ion detection unit, the method comprising:
causing the control unit to determine measurement time used for selected ion monitoring for each corresponding ion component based on start time and end time of each peak determined by a base line of each peak waveform of the one or a plurality of mass chromatogram data items.

7. The method of controlling a chromatograph mass spectrometer according to claim 6 ,
wherein the control unit sets, as the measurement time, time obtained by adding time with a predetermined range before and/or after a time range corresponding to the base line.

8. The method of controlling a chromatograph mass spectrometer according to claim 6 ,
wherein the control unit determines each peak waveform of the one or a plurality of mass chromatogram data items in parallel with an operation of detecting scanned data by the ion detection unit, and then determines the measurement time for each ion component.

9. The method of controlling a chromatograph mass spectrometer according to claim 6 ,
wherein the chromatograph unit is a liquid chromatograph.

10. The method of controlling a chromatograph mass spectrometer according to claim 6 ,
wherein the chromatograph unit is a gas chromatograph.

Assignees

• Hitachi High Tech Corp

Inventors

• Yoshioka Shinji
• Yamashita Hiromichi
• Maekawa Akira

Classifications

• G01N30/8644

  Data segmentation, e.g. time windows · CPC title

• G01N30/86 Primary

  Signal analysis · CPC title

• G01N30/7206

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• G01N30/8631

  Peaks · CPC title

• G01N30/8658 Primary

  Optimising operation parameters · CPC title