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Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
US9822112B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9822112-B2 |
| Application number | US-201715587679-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 5, 2017 |
| Priority date | Jan 14, 2015 |
| Publication date | Nov 21, 2017 |
| Grant date | Nov 21, 2017 |
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Abstract
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Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R 1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
First claim
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What is claimed is: 1. A compound having a structure represented by formula (IIa-02):
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Antineoplastic agents · CPC title
Drugs for disorders of the alimentary tract or the digestive system · CPC title
Drugs for disorders of the respiratory system · CPC title
- C07D487/04Primary
Ortho-condensed systems · CPC title
- C07D471/04Primary
Ortho-condensed systems · CPC title
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- What does patent US9822112B2 cover?
- Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R 1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate …
- Who is the assignee on this patent?
- Bristol Myers Squibb Co, Bristol-Meyers Squibb Company
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 21 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).