Devices and methods for parahydrogen induced polarization

Patent metadata

Field	Value
Publication number	US-9821290-B2
Application number	US-201314426454-A
Country	US
Kind code	B2
Filing date	Sep 6, 2013
Priority date	Sep 7, 2012
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

The present invention teaches devices and methods for hyperpolarization by parahydrogen induced polarization. The invention teaches several significant improvements over previous designs, including a heating block, an enhanced solenoid component, and pinch valves and tubing that provide a sterile environment for the sample. All of these advancements can be accomplished while keeping costs to produce the device relatively low.

First claim

What is claimed is:

1. A device for parahydrogen induced polarization, comprising:
(1) a reactor, comprising a first reactor inlet, a second reactor inlet, and a reactor outlet;
(2) a precursor receiving tube, comprising a first precursor receiving tube end and a second precursor receiving tube end, wherein the first precursor receiving tube end is mechanically connected to the first reactor inlet;
(3) a parahydrogen receiving tube, comprising a first parahydrogen receiving tube end and a second parahydrogen receiving tube end, wherein the first parahydrogen receiving tube end is mechanically connected to the second reactor inlet;
(4) an outlet tube, comprising a first outlet tube end and a second outlet tube end, wherein the first outlet tube end is mechanically connected to the reactor outlet;
(5) a radio frequency (RF) coil enveloping the reactor along the vertical axis thereof;
(6) a solenoid coil enveloping the RF coil along the vertical axis thereof; and
(7) a metal heating block, comprising a longitudinal axis comprising a plurality of grooves situated perpendicular thereto, wherein each of the plurality of grooves are configured to accommodate a section of the precursor receiving tube, and wherein the section of the precursor receiving tube is wrapped around the grooves of the metal heating block.

2. The device of claim 1 , further comprising one or more pinch valves rated at 25 PSI to be functional at pressures up to 100 PSI, wherein the pinch valves are configured to compress one or more segments of one or more of the precursor receiving tube, the parahydrogen receiving tube and the outlet tube.

3. A device for parahydrogen induced polarization, comprising:
(1) a reactor, comprising a first reactor inlet, a second reactor inlet, and a reactor outlet;
(2) a precursor receiving tube, comprising a first precursor receiving tube end and a second precursor receiving tube end, wherein the first precursor receiving tube end is mechanically connected to the first reactor inlet;
(3) a parahydrogen receiving tube, comprising a first parahydrogen receiving tube end and a second parahydrogen receiving tube end, wherein the first parahydrogen receiving tube end is mechanically connected to the second reactor inlet;
(4) an outlet tube, comprising a first outlet tube end and a second outlet tube end, wherein the first outlet tube end is mechanically connected to the reactor outlet;
(5) a radio frequency (RF) coil enveloping the reactor along the vertical axis thereof;
(6) a solenoid coil enveloping the RF coil along the vertical axis thereof;
(7) one or more pinch valves, wherein the pinch valves are configured to compress one or more segments of one or more of the precursor receiving tube, the parahydrogen receiving tube and the outlet tube; and
(8) a metal heating block comprising a longitudinal axis comprising a plurality of grooves situated perpendicular thereto, wherein each of the plurality of grooves are configured to accommodate a section of the precursor receiving tube, wherein the section of the precursor receiving tube is wrapped around the grooves of the metal heating block, and wherein the metal heating block is heated by conduction.

4. The device of claim 1 or 3 , wherein the solenoid coil further comprises end-ring loops and mid-ring loops comprised of wire, and wherein the wire is configured to increase center field homogeneity compared to a solenoid coil without the end-ring loops and the mid-ring loops.

5. The device of claim 1 , further comprising a fan situated below the metal heating block.

6. The device of claim 2 or 3 , further comprising electronic components configured to control one or more of (1) one or more of the valves of the system, (2) the solenoid coil and (3) the RF coil.

7. The device of claim 6 , wherein the operation of the electronic components is controlled by software.

8. The device of claim 7 , wherein the software is configured with instructions for the device to generate an RF transfer pulse sequence with excitation at a first bandwidth corresponding to a hydrogen nuclei and a second bandwidth corresponding to a hyperpolarizable nuclei, when the instructions are executed.

9. The device of claim 8 , wherein the hyperpolarizable nuclei is 13 C or 15 N.

10. The device of claim 9 , wherein the software includes instructions for the device to generate the RF transfer pulse sequence based on three required scalar coupling constants, comprising J 1H-2H , J 1H-X and J 2H-X , wherein X comprises a hyperpolarizable nuclei.

Assignees

• Cedars Sinai Medical Center

Inventors

• Wagner Shawn
• Agraz Jose
• Li Debiao

Classifications

• A61K49/06

  Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations · CPC title

• G01R33/5601

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• B01J19/088 Primary

  giving rise to electric discharges (for heating purposes H05B7/00; for the production of ozone C01B13/11, H01T19/00) · CPC title

• C07C69/67

  of saturated acids · CPC title

• G01R33/282 Primary

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title