Sorbent and chemical regeneration of dialysate

Patent metadata

Field	Value
Publication number	US-9821103-B2
Application number	US-201514983595-A
Country	US
Kind code	B2
Filing date	Dec 30, 2015
Priority date	Aug 18, 2011
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

The present invention generally relates to systems and methods for the regeneration of spent dialysis solutions. The present invention further relates to systems and methods for continuously regenerating spent dialysis solution during dialysis. The present invention further relates to systems and methods for conducting dialysis that further include using chemical and physical separators in conjunction with ion exchange cartridges and/or adsorption cartridges.

First claim

What is claimed is:

1. A method for regenerating spent dialysate comprising passing said spent dialysate, which contains urea, through at least one sorbent device capable of converting at least a portion of said urea to ammonia, and then passing said spent dialysate through a liquid-liquid counter-current extractor to remove at least a portion of said ammonia from said spent dialysate, wherein said sorbent device contains a source containing urease that hydrolyzes urea to ammonia to form an ammonia-containing dialysate solution from spent dialysate, and wherein said liquid-liquid counter-current extractor comprises a) at least one liquid immiscible with said ammonia-containing dialysate solution, wherein the at least one liquid is an organic solvent, and further comprises b) at least one extractor molecule contained in the liquid that removes ammonia from said ammonia-containing dialysate solution, wherein said ammonia-containing dialysate solution and said at least one liquid immiscible solution containing said at least one extractor molecule countercurrently pass through said liquid-liquid counter-current extractor, and wherein said at least one sorbent device is in fluid communication with a hemodialysis machine or peritoneal dialysis machine to receive said spent dialysate therefrom, and said liquid-liquid counter-current extractor is in fluid communication with said hemodialysis machine or peritoneal dialysis machine, wherein said liquid-liquid counter-current extractor produces regenerated dialysate that is returned by the fluid communication to the hemodialysis machine or peritoneal dialysis machine.

2. The method of claim 1 , further comprising passing said spent dialysate, after removing at least a portion of said ammonia, through one or more subsequent sorbent devices to further purify said spent dialysate.

3. The method of claim 2 , wherein said one or more subsequent sorbent devices comprise at least one cartridge capable of removing phosphate or a portion thereof, and/or capable of removing organic uremic toxins or a portion thereof.

4. The method of claim 1 , wherein said passing of said spent dialysate through said liquid-liquid counter-current extractor comprises countercurrently passing the spent dialysate containing ammonia and at least one liquid immiscible with dialysate solution containing an extractor molecule through said liquid-liquid counter-current extractor, wherein the extractor molecule is complexed with the ammonia removed from said spent dialysate to produce a complex.

5. The method of claim 4 , further comprising heating said at least one liquid and said complex after said countercurrently passing of said spent dialysate and said at least one liquid, to break said complex to release ammonia therefrom and regenerate the extractor molecule.

6. The method of claim 5 , further comprising expelling said ammonia from the liquid-liquid counter-current extractor after breaking said complex, and returning said at least one liquid and regenerated extractor molecule to said liquid-liquid counter-current extractor.

7. The method of claim 4 , wherein said extractor molecule is a cation exchange molecule.

8. The method of claim 4 , wherein said extractor molecule is a phosphinic acid, a carboxylic acid, a phosphoric acid, or any combination thereof.

9. The method of claim 4 , wherein said at least one liquid is undecane, Norpar 12, a vegetable oil, a modified vegetable oil, a biodiesel, or any combination thereof.

10. The method of claim 4 , wherein said extractor molecule removes from 95% to 100% by weight of all said ammonia from said spent dialysate.

Assignees

• Fresenius Medical Care Holdings Inc

Inventors

• Sandford Harold F

Classifications

• A61M1/14

  Dialysis systems; Artificial kidneys; Blood oxygenators (semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00){; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis} · CPC title

• A61M1/284

  Continuous flow peritoneal dialysis [CFPD] · CPC title

• A61M1/287

  Dialysates therefor · CPC title

• A61M1/28

  Peritoneal dialysis {; Other peritoneal treatment, e.g. oxygenation} · CPC title

• A61M1/3482

  by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter · CPC title