Composites comprising collagen extracted from sarcophyton sp. coral

Patent metadata

Field	Value
Publication number	US-9821089-B2
Application number	US-201314376891-A
Country	US
Kind code	B2
Filing date	Feb 7, 2013
Priority date	Feb 9, 2012
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

Isolated composites are disclosed comprising collagen fibers isolated from a Sarcophyton sp. coral. An exemplary composite comprises as a first component a bundle of collagen fibers, the collagen fibers being isolated from a Sarcophyton sp. coral, and a second component selected from the group consisting of a polysaccharide, a polypeptide, polylipid, a synthetic polymer, a metal and a mineral, wherein the bundle of collagen fibers comprise woven fibers, twisted fibers, braided fibers, knitted fibers, tied fibers, or sutured fibers. Uses thereof and method of generating are also disclosed.

First claim

What is claimed is:

1. An isolated composite comprising bundles of collagen fibers embedded in a matrix, said collagen fibers being isolated from a Sarcophyton sp. coral, and said matrix comprising a material selected from the group consisting of a polysaccharide, a polypeptide, polylipid, a synthetic polymer, a metal and a mineral, wherein said bundle of collagen fibers comprise woven fibers, twisted fibers, braided fibers, knitted fibers, tied fibers, or sutured fibers.

2. A wire composed of the composite of claim 1 .

3. The composite of claim 1 , wherein at least a portion of said first component and a portion of said second component are crosslinked.

4. A method of generating the collagen composite of claim 1 , comprising:
(a) manipulating said collagen fibers of said Sarcophyton sp. coral to generate a bundle of collagen fibers; and
(b) contacting said bundle of collagen fibers with said second component, thereby generating the collagen composite of claim 1 .

5. The method of claim 4 , wherein said manipulating is selected from the group consisting of weaving, twisting, braiding, knitting, tying and suturing.

6. The method of claim 4 , further comprising crosslinking said composite following said contacting.

7. The method of claim 4 , further comprising freeze-drying said composite following said contacting.

8. An implantable device comprising the composite of claim 1 .

Assignees

• Ramot At Tel-Aviv Univ Ltd

Inventors

• Haj-Ali Rami
• Benayahu Yehuda
• Benayahu Dafna
• Sason-Levi Aviad
• Sharabi Mirit

Classifications

• D06M13/00

  Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds (D06M10/00, D06M14/00 take precedence; treatment with complexes of organic amines with inorganic substances D06M11/59); Such treatment combined with mechanical treatment · CPC title

• D04B1/14

  Other fabrics or articles characterised primarily by the use of particular thread materials · CPC title

• D01G1/00

  Severing continuous filaments or long fibres, e.g. stapling · CPC title

• C08L89/06

  derived from leather or skin {, e.g. gelatin} · CPC title

• D01G13/00

  Mixing, e.g. blending, fibres; Mixing non-fibrous materials with fibres · CPC title