Process for preparing an aqueous solution of saccharides and methylcellulose

Patent metadata

Field	Value
Publication number	US-9820498-B2
Application number	US-201414771932-A
Country	US
Kind code	B2
Filing date	Apr 8, 2014
Priority date	Apr 12, 2013
Publication date	Nov 21, 2017
Grant date	Nov 21, 2017

Abstract

An aqueous solution comprising (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, is produced by i) mixing the methylcellulose with an aqueous liquid comprising one or more mono-, di- and/or oligosaccharides at a shear rate of at least 1000 s −1 or ii) mixing one or more mono-, di- and/or oligosaccharides with the methylcellulose and/or an aqueous liquid before, simultaneously with or after mixing the methylcellulose with the aqueous liquid at a shear rate of at least 1000 s −1 .

First claim

The invention claimed is:

1. An aqueous solution comprising
(a) one or more mono-, di- and/or oligosaccharides and
(b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less,
wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups,
wherein the concentration of the methylcellulose (MC) is from 0.2 to 2.5 percent and the aqueous solution has a gel fracture force F GF (37° C.) of

i) at least 1.2 N and up to 20 N when the MC concentration is from 0.2 to 0.4 percent,
ii) at least 1.5 N and up to 20 N when the MC concentration is from 0.5 to 0.7 percent,
iii) at least 2.0 N and up to 20 N when the MC concentration is from 0.8 to 1.0 percent,
iv) at least 3.0 N and up to 20 N when the MC concentration is from 1.1 to 1.3 percent,
v) at least 4.5 N and up to 20 N when the MC concentration is from 1.4 to 1.6 percent,
vi) at least 6.5 N and up to 75 N when the MC concentration is from 1.7 to 1.9 percent,
vii) at least 8.5 N and up to 75 N when the MC concentration is from 2.0 to 2.2 percent, or
viii) at least 12.0 N and up to 75 N when the MC concentration is from 2.3 to 2.5 percent,
based on the total weight of the aqueous solution.

2. The aqueous solution of claim 1 wherein the concentration of the methylcellulose (MC) is from 0.8 to 2.2 percent and the aqueous solution has a gel fracture force F GF (37° C.) of
at least 2.0 N and up to 20 N when the MC concentration is from 0.8 to 1.0 percent,
at least 3.0 N and up to 20 N when the MC concentration is from 1.1 to 1.3 percent,
at least 4.5 N and up to 20 N when the MC concentration is from 1.4 to 1.6 percent,
at least 6.5 N and up to 75 N when the MC concentration is from 1.7 to 1.9 percent, or
at least 8.5 N and up to 75 N when the MC concentration is from 2.0 to 2.2 percent,
based on the total weight of the aqueous solution.

3. The aqueous solution of claim 1 wherein the concentration of the methylcellulose (MC) is from 0.8 to 2.2 percent and the aqueous solution has a gel fracture force F GF (37° C.) of
at least 3.0 N and up to 20 N when the MC concentration is from 0.8 to 1.0 percent,
at least 4.5 N and up to 20 N when the MC concentration is from 1.1 to 1.3 percent,
at least 5.5 N and up to 20 N when the MC concentration is from 1.4 to 1.6 percent,
at least 8.5 N and up to 75 N when the MC concentration is from 1.7 to 1.9 percent, or
at least 10.0 N and up to 75 N when the MC concentration is from 2.0 to 2.2 percent,
based on the total weight of the aqueous solution.

4. The aqueous solution of claim 1 wherein the aqueous solution has been prepared by
i) mixing the methylcellulose with an aqueous liquid comprising one or more mono-, di- and/or oligosaccharides at a shear rate of at least 1000 s −1 , or
ii) mixing one or more mono-, di- and/or oligosaccharides with the methylcellulose and/or an aqueous liquid before, simultaneously with or after mixing the methylcellulose with the aqueous liquid at a shear rate of at least 1000 s −1 .

5. The aqueous solution of claim 1 wherein the viscosity of the methylcellulose is from 200 to 10000 mPa·s, when measured as a 2 wt. % solution in water at 5° C. at a shear rate of 10 s −1 .

6. The aqueous solution of claim 1 comprising from 2.0 to 25 percent of one or more mono-, di- and/or oligosaccharides, based on the total weight of the solution.

7. A medicament, food, food ingredient or food supplement comprising or being made of the aqueous solution of claim 1 .

8. A method of reducing caloric intake, inducing satiety or reversibly reducing stomach void volume in an individual or of treating gastric ulcers, gastro-esophageal reflux disease, or obesity, or of aiding slimming, weight loss, or weight control in a non-obese individual, comprising the step of administering to said individual the medicament, food, food ingredient or food supplement of claim 7 .

9. The method of claim 8 , wherein the individual is not obese.

10. A method of reducing caloric intake, inducing satiety or reversibly reducing stomach void volume in an individual or of treating gastric ulcers, gastro-esophageal reflux disease, or obesity, or of aiding slimming, weight loss, or weight control in a non-obese individual, comprising the step of administering to said individual the aqueous solution of claim 1 .

11. The method of claim 10 , wherein the individual is not obese.

Assignees

• Dow Global Technologies Llc

Inventors

• Deo Puspendu
• Adden Roland
• Knarr Matthias
• Sammler Robert L
• Brown Kathryn

Classifications

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A23L33/30

  Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence) · CPC title

• A23L33/24 Primary

  Cellulose or derivatives thereof · CPC title

• A61K31/717

  Celluloses · CPC title

• A23L29/262

  Cellulose; Derivatives thereof, e.g. ethers · CPC title