Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-9816046-B2
Application number	US-201715589572-A
Country	US
Kind code	B2
Filing date	May 8, 2017
Priority date	Mar 28, 2007
Publication date	Nov 14, 2017
Grant date	Nov 14, 2017

Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. A method of production of krill oil comprising:
obtaining a krill meal produced by a process comprising treating krill to destroy the activity of lipases and phospholipases naturally present in krill and wherein said krill meal has been stored for period of from 1 to 36 months; and
extracting krill oil from said krill meal that has been stored from 1 to 36 months with a polar solvent to provide a krill oil with greater than 30% phosphatidylcholine w/w of said krill oil and astaxanthin esters.

2. The method of claim 1 , wherein said krill oil comprises less than 3% free fatty acids w/w of said krill oil.

3. The method of claim 1 , wherein said krill oil comprises less than about 2% lysophosphatidylcholine w/w of said krill oil.

4. The method of claim 1 , wherein said process comprising treating krill to destroy the activity of the lipases and phospholipases naturally present in krill comprises grinding said krill prior to destroying the activity of said lipases and phospholipases naturally present in krill.

5. The method of claim 1 , wherein said process comprising treating krill to destroy the activity of the lipases and phospholipases naturally present in krill comprises heating said krill.

6. The method of claim 1 , wherein said process comprising treating krill to destroy the activity of the lipases and phospholipases naturally present in krill comprises treating said krill with chemicals.

7. The method of claim 1 , wherein said process comprising treating krill to destroy the activity of the lipases and phospholipases naturally present in krill comprises a combination of heating said krill and treating said krill with chemicals.

8. The method of claim 1 , further comprising encapsulating said krill oil.

9. The method of claim 3 , wherein said krill is Euphausia superba.

10. The method of claim 1 , wherein said krill oil comprises at least 40% phosphatidylcholine w/w of said krill oil.

11. The method of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 100 mg/kg.

12. The method of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 200 mg/kg.

13. A method of production of Euphausia superba krill oil comprising:
a) obtaining a Euphausia superba krill meal produced by a process comprising treating Euphausia superba to destroy the activity of lipases and phospholipases naturally present in Euphausia superba and wherein said Euphausia superba krill meal has been stored from 1 to 36 months; and
b) extracting Euphausia superba oil from said krill meal that has been stored from 1 to 36 months with a polar solvent to provide a Euphausia superba krill oil comprising greater than 30% phosphatidylcholine w/w of said Euphausia superba krill oil, less than 3% free fatty acids w/w of said Euphausia superba krill oil, and at least 100 mg/kg astaxanthin esters.

14. The method of claim 13 , further comprising encapsulating said Euphausia superba krill oil.

15. The method of claim 13 , wherein said krill oil comprises at least 40% phosphatidylcholine w/w of said Euphausia superba krill oil.

16. The method of claim 13 , wherein said process comprising treating Euphausia superba to destroy the activity of the lipases and phospholipases naturally present in Euphausia superba comprises grinding said Euphausia superba prior to destroying the activity of said lipases and phospholipases naturally present in Euphausia superba.

17. The method of claim 13 , wherein said process comprising treating Euphausia superba to destroy the activity of the lipases and phospholipases naturally present in Euphausia superba comprises heating said Euphausia superba.

18. The method of claim 13 , wherein said process comprising treating Euphausia superba to destroy the activity of the lipases and phospholipases naturally present in Euphausia superba comprises treating said Euphausia superba with chemicals.

19. The method of claim 13 , wherein said process comprising treating Euphausia superba to destroy the activity of the lipases and phospholipases naturally present in Euphausia superba comprises a combination of heating said Euphausia superba and treating said Euphausia superba with chemicals.

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K31/20

  having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids · CPC title

• A61K31/235

  having an aromatic ring attached to a carboxyl group · CPC title

• A61K31/575

  substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title

• A61K31/215

  of carboxylic acids · CPC title