Inhibiting peptides derived from TREM-like transcript 1 (TLT-1) and uses thereof

Patent metadata

Field	Value
Publication number	US-9815883-B2
Application number	US-201514699620-A
Country	US
Kind code	B2
Filing date	Apr 29, 2015
Priority date	Apr 8, 2010
Publication date	Nov 14, 2017
Grant date	Nov 14, 2017

Abstract

The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis.

First claim

The invention claimed is:

1. A method for reversing, alleviating, or inhibiting the progress of an inflammatory condition, comprising administering to a subject in need thereof a polypeptide of 6 to 12 amino acids comprising at least 6 consecutive amino acids from the amino acid sequence SEQ ID NO 9, wherein said inflammatory condition is an inflammatory condition in which TREM-1 activation plays a role in amplifying inflammation selected from the group consisting of inflammatory bowel disease, acute respiratory distress syndrome (ARDS), pancreatitis, pneumonia, systemic inflammatory response syndrome (SIRS), severe acute respiratory syndrome (SARS), sepsis, severe sepsis, septic shock, endotoxemia and hemorrhagic shock, and wherein said polypeptide comprises SEQ ID NO 8.

2. The method according to claim 1 , wherein the inflammatory condition is selected from the group consisting of acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), severe acute respiratory syndrome (SARS), sepsis, severe sepsis, septic shock and endotoxemia.

3. The method according to claim 1 , wherein the inflammatory condition is sepsis or septic shock.

4. The method according to claim 1 , wherein said polypeptide consists of the amino acid sequence as set forth in SEQ ID NO: 9.

Assignees

• Gibot Sebastien
• Derive Marc
• Institut National De La Sante Et De La Rech Medicale (Inserm)
• Univ De Lorraine

Inventors

• Gibot Sebastien
• Derive Marc

Classifications

• A61P31/04

  Antibacterial agents · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K14/70503 Primary

  Immunoglobulin superfamily · CPC title

• A61K38/10

  Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title